Trevena, Inc.

89bio, Inc.

Arbutus Biopharma Corporation

Cephalon, Inc.

Trevana, Inc.

Dimitar B Gotchev

Bruce D Dorsey

Robert L Hudkins

Philip Michael Pitis

Dennis Shinji Yamashita

Xiao-Tao Chen

Craig A Zificsak

Nadine C Becknell

Reddeppa Reddy Dandu

Catherine C K Yuan

Guodong Liu

Linda Weinberg

Allison L Zulli

Shuai Chen

Duyan Nguyen

Yingzhi Bi

Mark Wood

Richard James Holland

Ramesh Kakarla

Laurèn Danielle Bailey

Yi Fan

Ganapati Reddy Pamulapati

Jorge Quintero

Mahesh Kumar Pallerla

Catherine CK Yuan

Mark Christopher Wood

Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds. Also described herein are methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.

Substituted 4-benzyl and 4-benzoyl piperidine derivates

Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.

1,4-substituted piperidine derivatives

This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.

Opioid receptor ligands and methods of using and making same

The present invention includes in one aspect substituted 2-oxo-1,2,5,6-tetrahydrobenzo[h]quinoline-3-carboxylic acids, analogues thereof, and compositions comprising the same, which can be used to treat and/or prevent hepatitis B virus (HBV) infection and/or hepatitis D virus (HDV) in a patient. In certain embodiments, the invention provides a compound of formula (I), or a salt, solvate, geometric isomer, stereoisomer, tautomer, and any mixtures thereof:

Substituted 2-pyridone tricyclic compounds, analogues thereof, and methods using same

The present disclosure relates to novel, scalable methods of making substituted tricyclic compounds that are useful to treat and/or prevent HBV and/or HBV-HDV infection and related conditions in a subject.

Methods for preparing substituted pyridinone-containing tricyclic compounds

The present invention includes substituted pyridinone-containing tricyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient. In certain embodiments, the compounds and compositions of the invention inhibit and/or reduce HBsAg secretion.

Substituted pyridinone-containing trycyclic compounds, and methods using same

Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds. Also described herein are methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses. 

Substituted 4-benzyl and 4-benzoyl piperidine derivatives

Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses. 

Growing community of inventors

Hatboro, PA, United States of America

Dimitar B Gotchev