Archemix Corporation

Dilara Grate

Charles Wilson

Thomas Greene McCauley

John Louis Diener

David Epstein

Markus Kurz

Jeffrey C Kurz

Martin Stanton

Claude Benedict

James Rottman

Kristin Thompson

Sara Chesworth Keene

Anna J Zoltoski

Nobuko Hamaguchi

Kristin A Marshall

Tony Keefe

Errol Desouza

Jeffrey Kurz

Thomas Green Mccauley

John Deiner

Thomas Mccauley

Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.

Aptamers comprising CPG motifs

Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics

The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.

Aptamer therapeutics useful in the treatment of complement-related disorders

Methods for engineering a nucleic acid sensor molecule are provided. Biosensors comprise a plurality of nucleic acid sensor molecules labeled with a first signaling moiety and a second signaling moiety. The nucleic acid sensor molecules recognizes target molecules which do not naturally bind to DNA. Binding of a target molecule to the sensor molecules triggers a change in the proximity of the signaling moieties which leads to a change in the optical properties of the nucleic acid sensor molecules on the biosensor. Reagents and systems for performing the method are also provided. The method is useful in diagnostic applications and drug optimization.

Nucleic acid sensor molecules and methods of using same

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Waltham, MA, United States of America

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