Bayer Healthcare LLC

Ascensia Diabetes Care Holdings Ag

Bayer Corporation

Miles Inc.

Dijia Huang

Andrew J Edelbrock

Steven C Charlton

Huan-Ping Wu

Sung-Kwon Jung

Matthew K Musho

Amy H Chu

Suny J George

J Oakey Noell

John P Creaven

Kin F Yip

Weiping Zhong

Marvin A Genshaw

Ping Wu

Joseph E Perry

Russell J Micinski

Daniel V Brown

Kin-Fai Yip

Willis E Howard, Iii

Joseph E Ruggiero

Gerald H Shaffer

Julianne M Guarino

Brenda L Tudor

Michael G Kahn

Stephen A Bussmann

Steve B Cousins

Charlene A Abrams

James C Beard

Robert W Rogers

Mark A Yoder

Stephen Bussman

M Dee Omundson

Lawrence J Burns

A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the &#x2212;0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.

Determining analyte concentration from variant concentration distribution in measurable species

A biosensor system determines analyte concentration from analytic and/or secondary output signals. The biosensor system adjusts a correlation for determining analyte concentrations from output signals with one or more index functions extracted from the output signals. The index functions determine at least one slope deviation or normalized slope deviation from one or more error parameters. The slope-adjusted correlation between analyte concentrations and output signals may be used to determine analyte concentrations having improved accuracy and/or precision from output signals including components attributable to bias.

Slope-based compensation including secondary output signals

Systems and methods for electrochemically oxidizing components of a test-sensor reagent prior to deposition on a test sensor comprise at least a first electrode and a second electrode for contacting the test-sensor reagent. The first electrode and the second electrode may have hollow interior portions for contacting the test-sensor reagent to produce a modified test-sensor reagent having a reduced background current.

Method for forming an optical test sensor

Slope-base compensation including secondary output signals

According to one embodiment of the present invention, an electrochemical sensor () for detecting the concentration of analyte in a fluid test sample is disclosed. The sensor () includes a counter electrode having a high-resistance portion for use in detecting whether a predetermined amount of sample has been received by the test sensor.

Electrochemical biosensor

Method for forming a test sensor

Transient decay amperometry biosensors

An electrochemical test sensor adapted to assist in determining the concentration of analyte in a fluid sample is disclosed. The sensor comprises a base that assists in forming an opening for introducing the fluid sample, a working electrode being coupled to the base, and a counter electrode being coupled to the base, the counter electrode and the working electrode being adapted to be in electrical communication with a detector of electrical current, and a sub-element being coupled to the base. A major portion of the counter electrode is located downstream relative to the opening and at least a portion of the working electrode. The sub-element is located upstream relative to the working electrode such that when electrical communication occurs between only the sub-element and the working electrode there is insufficient flow of electrical current through the detector to determine the concentration of the analyte in the fluid sample.

Electrochemical-sensor design

Methods of using an electrochemical biosensor

A method of operating a meter for determining the concentration of an analyte in a current sample and for self-detecting electrical connection errors like short or open circuit between the electrodes of a biosensor. The method includes providing a connector with a plurality of contacts and coupling each of the plurality of contacts to one of a plurality of electrical leads on a biosensor, such that each of the plurality of connector contacts electrically contacts a corresponding one of the plurality of electrical leads. The meter obtains a first measurement between a pair of the plurality of connector contacts prior to the fluid sample being applied. The meter also obtains a second measurement between the pair of the plurality of connector contacts after the fluid sample is applied. In response to either the first or the second measurements being outside a predetermined range, a fault is indicated.

Method and system for checking an electromechanical biosensor

Transient decay amperometry

Systems for forming reagent with reduced background current

Growing community of inventors

Granger, IN, United States of America

Dijia Huang