Bayer Aktiengesellschaft

Lanxess Deutschland Gmbh

Bayer Healthcare Aktiengesellschaft

Dietrich Seidel

Rudolf Schohe-Loop

Rolf Grosser

Andreas Krebs

Hanns-Ingolf Paul

Alfons Grunenberg

Walter Lange

Herbert Diehl

Frank Mauler

Michael Conrad

Wolfgang Karl

Tobias Reichelt

Dietrich Scherling

Corinna Weinz

Elvira Krebs, Legal Representative

Oliver Brehm

The present invention relates to a process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane with the aid of continuous countercurrent chromatography, which is also described as SMB chromatography (SMB=simulated moving bed). In a further aspect, the invention relates to a process for the preparation of (1S,6R)-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane using the aforementioned process, which furthermore includes a racemization step.

Process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane

The present invention relates to chromans, to processes for their preparation and to their use in medicaments, in particular as agents for treating disorders of the central nervous system.

Benzisothiazolyl-substituted aminomethyl chromanes for treating diseases of the central nervous system

The invention relates to the crystalline form of the hydrochloride of the compound (R)-(-)-2-{N-�4-(1,1-dioxido-3-oxo-2,3-dihydro-benzisothiazol-2-yl)-butyl! -aminomethyl}-chroman, which is present as a stable form at room temperature. The crystalline modification V of the hydrochloride is suitable in particular for the preparation of solid medicaments, in particular of medicaments for the treatment of neuronal degenerations.

Crystalline hydrochloride of

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Wuppertal, Germany

Dietrich Seidel