Other

Eli Lilly and Company

Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts

Boehringer Ingelheim International Gmbh

Dietrich Keppler

Gabriele Jedlitschky

Inka Leier

Joerg Koenig

Jörg König

Described is a double-transfected cell line containing (a) a DNA sequence encoding an uptake transporter for organic anions, preferably OATP8, operatively linked with a promoter and (b) a DNA sequence encoding an export pump for organic anions or anionic conjugates, preferably the multidrug resistance protein 2 (MRP2), operatively linked with a promoter. Moreover, various uses of said cell line are described, preferably its use for the identification of transport inhibitors, e.g. drug candidates.

Double-transfected cell line useful for the identification of transport inhibitors

This invention provides a method of identifying and reversing multidrug resistance in a multidrug resistant tumor comprising administering a multidrug resistance reversing amount of any of the compounds as defined herein.

Methods for identifying and treating resistant tumors

This invention provides a method of identifying and reversing multidrug resistance in a multidrug resistance tumor comprising administering a multidrug resistance reversing amount of any of the compounds as defined herein.

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Dossenheim, Germany

Dietrich Keppler