Bayer Aktiengesellschaft

Dietrich Horlein

Eugen Schnabel

Gerd Reinhardt

Michael Schedel

Wolfgang Bruns

Werner Schroder

Ernst-August Auerswald

Rathindra Das

Jurgen Ebbers

Peptides having essentially the sequence of bovine pancreatic trypsin inhibitor (aprotinin) wherein one or more of the amino acids at positions 15, 16, 17, 18, 34, 39 and 52 are replaced by any naturally occurring amino acid produced by recombinant DNA technology, process, expression vector and recominant host therefor and pharmaceutical use thereof. Such peptides being useful as therapeutic agents in diseases connected with the presence of excessive amounts of proteinases.

Variants of bovine pancreatic trypsin inhibitor produced by recombinant

An aprotinin with a deletion of the amino acid proline in position 2 or an addition of alanine-(-2)-glutamine-(-1). Such aprotinin is useful as an active ingredient in medicaments.

Recombinant aprotinin variants genetically engineered process for the

An aprotinin with a deletion of the amino acid proline in position 2 or an addition of alanine-(-2)- glutamine-(-1). Such aprotinin is useful as an active ingredient in medicaments.

Variants of bovine pancreatic trypsin inhibitor and pharmaceutical use

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Wuppertal, Germany

Dietrich Horlein