Hoechst Aktiengesellschaft

Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Dietrich Brocks

Stephan Henke

Volkmar Gunzler

Hartmut Hanauske-Abel

Martin Bickel

Harald Burghard

Georg Tschank

Jurgen Mohr

Rupert Timpl

Ekkehard Baader

Kari I Kivirikko

Mats Paulsson

Volker Teetz

Volkmar Gunzler-Pukall

Helmut Strecker

Helmut Strecker, Deceased

Henning Hachmann

Horst Neubauer

Volkmar Gunzlen-Pukall

Raili M Myllyla

Volkmar Gunzier

Jurgen Punter

Volkmar G Unzler

Kari Majamaa

It is possible with the aid of a monoclonal antibody which is specifically directed against an epitope of amino-terminal procollagen peptide (type III) which is not present on the fragment Col 1, and of a second monoclonal or polyclonal antibody against an epitope of amino-terminal procollagen peptide (type III), to determine said peptide with great accuracy. It is also, possible, with the aid of a monoclonal antibody which is specifically directed against an epitope of amino-terminal procollagen peptide (type III) which is not present in Col 1, to determine with great accuracy said procollagen peptide in body fluids.

Monoclonal antibodies for the selective immunological determination of

The invention relates to pyridine-2,4- and -2,5-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and X have the meanings given, a process for the preparation of these compounds and their use, in particular in medicaments for influencing the metabolism of collagen and collagen-like substances or the biosynthesis of Cl.sub.q.

Pharmaceutical use of pyridine-2,4- and -2,5-dicarboxylic acid amides

The invention relates to compounds of the formula ##STR1## in which A denotes an optionally substituted radical from the series comprising alkyl, acyl, cycloalkyl, aryl and heteroaryl; A.sup.1 represents CO, CS, C.dbd.NH, CN-alkyl, CN--O-alkyl, SO, optionally substituted CH.sub.2 or a bond; A.sup.2 represents NH, NCH.sub.3, O, CH.sub.2 or a bond; E represents CHOH, CO, SO or optionally N-substituted C.dbd.NH; A.sup.3 represents O, NH, NCH.sub.3 or a bond; R.sup.4 denotes an optionally substituted radical from the series comprising alkyl, cycloalkyl, aryl and heteroaryl; and R.sup.8 denotes hydrogen or optionally substituted alkyl, to a process for their preparation, and to their use as inhibitors of prolyl hydroxylase.

2,3-disubstituted isoxazolidines, a process for their preparation,

The invention relates to pyridine-2,4- and -2,5-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1, R.sup.2, 3.sup.3, R.sup.4 and X have the meanings given, a process for the preparation of these compounds and their use, in particular in medicaments for influencing the metabolism of collagen and collagen-like substances or the biosynthesis of Cl.sub.q.

Medicaments based on pyridine-2,4- and 2,5-dicarboxylic acid amides

The invention relates to compounds of the formula ##STR1## in which A denotes an optionally substituted radical from the series comprising alkyl, acyl, cycloalkyl, aryl and heteroaryl; A.sub.1 represents CO, CS, C=NH, CN-alkyl, CN-O-alkyl, SO, optionally substituted CH.sub.2 or a bond; A.sub.2 represents NH, NCH.sub.3, O, CH.sub.2 or a bond; E represents CHOH, CO, SO or optionally N-substituted C=NH; A.sub.3 represents O, NH, NCH.sub.3 or a bond; R.sup.4 denotes an optionally substituted radical from the series comprising alkyl, cycloalkyl, aryl and heteroaryl; and R.sup.8 denotes hydrogen or optionally substituted alkyl, to a process for their preparation, and to their use as inhibitors of prolyl hydroxylase.

2,3-disubstituted isoxazolidines, agents containing them and their use

The invention relates to pyridine-2,4- and -2,5-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1, R.sup.2 and X have the meanings given, a process for the preparation of these compounds and their use, in particular in medicaments for influencing the metabolism of collagen and collagen-like substances or the biosynthesis of C1.sub.q.

Pyridine-2,4- and dicarboxylic acid derivatives, the use thereof and

The invention relates to substituted pyridine-2,4-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1 and R.sup.2 have the meanings given. The invention also relates to a process for the preparation of the abovementioned compounds and to their use as medicaments, in particular as fibrosuppressants and immunosuppressants.

Substituted pyridine-2,4-dicarboxylic acid compounds and the use thereof

Pyridine-2,4- and -2,5-dicarboxylic acid derivatives and medicaments

The invention relates to compounds of the formula I ##STR1## in which A denotes an optionally substituted radical from the series comprising alkyl, acyl, cycloalkyl, aryl and heteroaryl; Cyc represents an optionally substituted heterocyclic carbonyl compound; D represents NH, NCH.sub.3, O or CH.sub.2 ; E represents CHOH, CO, SO or optionally N-substituted C.dbd.NH; F represents O, NH, NCH.sub.3 or a bond; R.sup.4 denotes an optionally substituted radical from the series comprising alkyl, cycloalkyl, aryl and heteroaryl; and R.sup.8 denotes hydrogen or optionally substituted alkyl, to a process for the preparation thereof, and to the use thereof as inhibitors of prolyl hydroxylase.

Oligopetides with cyclic proline-analogous amino acids

The invention relates to a method for the immunological determination of basal membrane low-density heparan sulfate-proteoglycan in body fluids, and to the preparation or obtaining of a low-density heparan sulfate-proteoglycan suitable for this purpose, and of the corresponding highly specific antibodies.

Method for the immunological determination of heparan

Pyridine-2,4- and -2,5-dicarboxylic acid amides and their medicinal

Basement membrane proteins are isolated as functioning proteins in relatively large amounts from human or animal tissues in aqueous solution in the presence of a chelating agent. It is possible to use these proteins to obtain highly specific antibodies which are used for the immunological determination of these proteins.

Process for the isolation of basement membrane proteins from human and

Substituted pyridine-2,4-dicarboxylic acid compounds and methods of use

The invention relates to pyridine-2,4- and -2,5-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and X have the meanings given, a process for the preparation of these compounds and their use, in particular in medicaments for influencing the metabolism of collagen and collagne-like substances or the biosynthesis of Cl.sub.q.

Growing community of inventors

Wiesbaden, Germany

Dietrich Brocks