Roche Diagnostics Operations, Inc.

Dietmar Volz

Uwe Kraemer

Heinz-Michael Hein

A method is proposed for the selective determination of a light transport parameter which is characteristic for the light scattering in a biological matrix (), in particular for the purpose of the non-invasive determination of the glucose concentration in the biological matrix. The method comprises providing a plurality of detection measurements, in which light is irradiated as primary light into the biological matrix and measuring an intensity value of secondary light emerging at a plurality detection sites, located in different measuring distances from the irradiation site. In an evaluation step, the light transport parameter is derived, by means of an evaluation algorithm, from the measured intensity values. For the selective determination of the scattering coefficient, the evaluation algorithm includes a step in which a time derivative value &#x394;I(r) describing the change of the measurement intensity value versus time is calculated from intensity measurement values obtained at a minimum of two different points of time.

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Dossenheim, Germany

Dietmar Volz