Basf Aktiengesellschaft

Abbott Gmbh & Co Kg

Abbvie Deutschland Gmbh and Co Kg

Dietmar Seemann

Wilfried Lubisch

Wilfried Hornberger

Andreas Kling

Helmut Mack

Achim Moeller

Volker Nimmrich

Manfred Raschack

Sabine Schult

Rudolf Binder

Roland Reinhardt

The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. The carboxamide compounds are compounds of the general formula I in which R, R, R, R, W, Y and X have the meanings mentioned in the claims and the description, the tautomers thereof and the pharmaceutically suitable salts thereof. In particular, the compounds have the general formula I-A.a' and I-A.a&#x2033; in which m, E, R, R, R, R, R, Rand Rhave the meanings mentioned in the claims, n is 0, 1 or 2, the tautomers thereof and the pharmaceutically suitable salts thereof.

Carboxamide compounds and their use as calpain inhibitors

The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. The carboxamide compounds are compounds of the general formula I in which R, R, R, R, W, Y and X have the meanings mentioned in the claims and the description, the tautomers thereof and the pharmaceutically suitable salts thereof. In particular, the compounds have the general formula I-A.a' and I-A.a&#x2033; in which m, E, R, R, R, R, R, Rand R* have the meanings mentioned in the claims, n is 0, 1 or 2, the tautomers thereof and the pharmaceutically suitable salts thereof.

Phenylpiperidylamines of the formula I ##STR1## R.sup.1 is H, NO.sub.2, R.sup.4 SO.sub.2 NH, ##STR2## N.dbd.C, CF.sub.3, CF.sub.3 O, F, Cl, Br, C.sub.1 -C.sub.4 -alkyl, R.sup.3 O, CO.sub.2 R.sup.3, CHO, CH.dbd.NOR.sup.3, CH.sub.3 OR.sup.3 and

Phenylpiperidylamines and drugs containing them

Phenylpiperidinylamines of the formula I ##STR1## where R.sup.1 is --NHSO.sub.2 R.sup.4 or ##STR2## R.sup.2 and R.sup.3 are each, independently of one another, H or C.sub.1 -C.sub.4 -alkyl or together are a (CH.sub.2).sub.n chain with n=4 or 5, and

Phenylpiperidinylamines and drugs containing these

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Nussloch, Germany

Dietmar Seemann