Sandoz Gmbh

Sandoz Pharm. Corp.

Dieter Sorg

Albert Leutwiler

Thiazoles or pharmaceutically acceptable acid addition salts thereof are useful as anxiolytic, psychogeriatric, antidepressant and antischizophrenic agents.

1-substituted-4-(thiazolyl-2-)-piperazines, -piperidines and

##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 4 carbon atoms, hydroxyalkyl with a maximum of 4 carbon atoms, the hydroxy group of which may be acylated by an alkanoyl group of 2 to 18 carbon atoms, alkoxyalkyl with a maximum of 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, cycloalkylalkyl of 4 to 7 carbon atoms, or a group of formula II, ##STR2## wherein R.sub.6 is hydrogen, halogen, or alkyl or alkoxy of 1 to 4 carbon atoms, and either

Pyrazinobenzodiazepines

The present invention concerns novel 2-(1-piperazinyl)-thiazole derivatives of the formula, ##STR1## wherein R.sub.1 is alkyl or cycloalkly,

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Bern, Switzerland

Dieter Sorg