Other

Merck Patent Gmbh

Biomet Deutschland Gmbh

Nexilis Ag

Technische Universitä{umlaut Over ( )}T Dresden

Technische Universitát Dresden

Friadent Gmbh

Dieter Scharnweber

Hartmut Worch

Sophie Roessler

Curt Kranz

Wolfgang Pompe

Thomas Hanke

Michel Dard

Bernd Schwenzer

Henrike Bersch

Jurgen Hofinger

Martina St&ouml;lzel

Sophie R&ouml;ssler

Michael Thieme

Andreas Sewing

Jan Michael

René Beutner

Susanne Bierbaum

Klaus Becker

The invention relates to an osteogenic composite matrix consisting of collagen and non-collagen components of an extracellular matrix (ECM-components), to a method for producing said matrix, to a method for producing an implant or a scaffold for tissue engineering which is provided with a coating formed by said osteogenic composite matrix and is used for stimulating and accelerating a hard tissue formation such as, for example. The implant osseointegration in bones. The inventive osteogenic composite matrix comprises a collagen and at least one non-collagen ECM component or the derivatives thereof, wherein the collagen component consists of non-crosslinked collagen fibers produced by fibrillogenesis and the non-collagen ECM component or the derivatives thereof are integrated into said collagen fibers.

Osteogenic composite matrix, method for the production thereof and implant and scaffold for tissue engineering provided with a coating formed by said osteogenic composite matrix

A metallic object has a coating made of a thin metal oxide layer and nucleic acids or nucleic acid derivatives bonded thereto. The nucleic acid compounds have 5'-terminal or 3&#x2032;-terminal molecule areas that are incorporated stably into the metal oxide layer. The unincorporated areas of the nucleic acid compounds that are not incorporated into the metal oxide layer are freely accessible for subsequent interactions with other molecules such as complementary nucleic acids having active ingredients attached thereto.

Metallic object with a nucleic acid coating and derivatives thereof and method for producing said object

A biomimetically produced bone-analogous coating, comprising organic and inorganic main constituents, is suitable for coating metallic implant materials of any desired surfaces. The coating comprises a collagen matrix mineralized with calcium phosphate.

Process for the coating for metallic implant materials

A metallic object, having a metallic substrate of a valve metal or a valve metal alloy inclusive of intermetallic phases, and a thin polyphase oxide coating, is disclosed. The polyphase oxide coating has a metal oxide phase and at least one other organic and/or inorganic phase. The polyphase oxide coating is produced by bringing the metallic substrate into contact with an organic and/or inorganic component to be integrated into the polyphase oxide coating such that the inorganic and/or organic phases are present at or in the direct vicinity of the substrate surface and by simultaneously or subsequently anodically polarizing the substrate material in an electrolytic solution.

Metallic object with a thin polyphase oxide coating and process for the manufacture thereof

Process for producing a gradient coating made of calcium phosphate

Growing community of inventors

Dresden, Germany

Dieter Scharnweber