Schering Aktiengesellschaft

A/s Ferrosan

Shering Ag

Scherling Ag

Schering Aktiengeseellschaft

Dieter Rahtz

Andreas Huth

Ralph Schmiechen

Dieter Seidelmann

Mogens Engelstoft

Helmut Biere

David N Stephens

Claus T Braestrup

Herbert H Schneider

Wolfgang Kehr

Ulrich Eder

Lechoslaw Turski

Gunter Neef

John Bondo Hansen

Martin Kruger

Dieter Palenschat

Ralph Rohde

Henning Koch

Peter Holscher

Peter A Loschmann

Joergen A Christensen

Frank Waetjen

Tage Honore

Jogen A Christensen

Mogens C Nielsen

Ingrid Schumann

Henning Schou

Ilse Beetz

Bondo John Hansen

Helmut Wachtel

Eberhard Schroder

Reinhard Horowski

Guenter Neef

Hans Wendt

Gert Paschelke

Erich Gerhards

John S Andrews

Helmut Schmiechen

Preben Olsen

The disclosure relates to quinoxaline derivates of Formula I

Quinoxaline-carboxylic acid derivatives

The disclosure relates to quinoxaline derivatives of Formula I ##STR1## wherein R.sup.1, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are as defined in the disclosure, as well as their production and use in medicinal agents.

Quinoxaline-phosphonic acid derivatives

5- or 6-substituted .beta.-carboline-3-carboxylic acid esters of Formula I ##STR1## wherein R.sup.1 is hydrogen, nitrilo, halogen, lower alkyl or lower alkoxy, and

5- or 6-substituted .beta.-carboline-3-carboxylic acid esters

.beta.-carbolines of formula I are described ##STR1## in which R.sup.A is a C.sub.6-12 aryl hetaryl as defined herein, that can be substituted singly to multiply with halogen, C.sub.1-4 -alkoxy, C.sub.1-4 -alkyl or amino,

.beta.-carboline derivatives for use as pharmaceutical agents

Beta-carbolines, process for their production and their use in

A .beta.-carbolin-3-carboxylic acid derivative of the formula ##STR1## wherein: X is oxygen, sulphur or NR.sup.10, wherein R.sup.10 is hydrogen, C.sub.1-6 -alkyl, C.sub.1-6 -alkenyl, C.sub.3-7 -cycloalkyl or C.sub.3-7 -cycloalkenyl;

.beta.-carbolin-3-carboxylic acid derivatives useful for treating

Heteroaryloxy-.beta.-carboline derivatives of general Formula I ##STR1## wherein R.sup.1 is an optionally substituted heteroaryl residue,

Heteroaryloxy-.beta.-carboline derivatives, their preparation and their

Imidazole derivatives

A process is disclosed for the preparation of 4-alkoxyalkyl .beta.-carboline derivatives of general Formula I ##STR1## wherein R.sup.1 is hydrogen or methyl,

Process for the preparation of 4-alkoxyalkyl .beta.-carbolines

.beta.-Carbolines of general Formula I ##STR1## wherein Y represents the residue ##STR2## and R.sup.a and R.sup.b, being identical or different, mean respectively hydrogen, C.sub.1-6 -alkoxy, phenyl, C.sub.3-7 -cyclo-alkyl, optionally substituted C.sub.1-6 -alkyl or C.sub.1-6 -alkoxycarbonyl, and R.sup.c and R.sup.d, being identical or different, mean respectively hydrogen or C.sub.1-6 -alkyl or jointly a linkage, and

Isoxazole-.beta.-carboline derivatives

.beta.-Carbolines of general Formula I ##STR1## wherein R.sup.3 is ##STR2## or --COOR', wherein R' is C.sub.1-3 alkyl or C.sub.3-6 cycloalkyl and R' is C.sub.1-4 alkyl; R.sup.4 is hydrogen, methyl, ethyl or methoxymethyl; and R.sup.A is ##STR3## wherein X is C.sub.1-12 straight-chain, branched-chain, saturated or unsaturated alkyl or a corresponding alkyl group with a CH.sub.2 -group substituted by a carbonyl group and R'' is one or more of fluorine, chlorine, bromine, or iodine, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, C.sub.1-5 acyloxy, phenyl, C.sub.2-5 alkylenedioxy, trifluoromethyl, nitrilo, nitro or --NR.sup.IV R.sup.V wherein R.sup.IV and R.sup.V, which can be the same or different are hydrogen, C.sub.1-3 alkyl, C.sub.1-5 acyl or phenyl, or collectively with the amido nitrogen atom form a 3- to 6-membered hetero ring, which are prepared conventionally by esterifying a corresponding compound wherein R.sup.A is H or R.sup.3 is --COOH, exhibit effects on the central nervous system and can be used as psychorharmaceuticals.

.beta.-carbolines and their use as medicinal agents

Heteroaryloxy-beta-carboline derivatives, their preparation and their

5,6,7,8-tetrahydro-beta-carbolines derivatives of formula I ##STR1## wherein R.sup.1 is an oxadiazolyl radical of the formula ##STR2## COOR.sup.3 or CONR.sup.4 R.sup.5, R.sup.2 is H, lower alkyl or cycloalkyl,

Tetrahydro-beta-carbolines, and their use as drugs

Compounds of formula I ##STR1## wherein n is 0 or 1,

3-oxadiazolyl-5-aminoalkyl-beta-carboline derivatives compositions and

Growing community of inventors

Berlin, Germany

Dieter Rahtz