Bayer Aktiengesellschaft

Dieter Petzinna

Hilmar Bischoff

Peter Fey

Delf Schmidt

Rolf Angerbauer

Walter Hubsch

Thomas Philipps

Gunter Thomas

Siegfried Goldmann

Walter Puls

Klaus Schlossmann

Joachim Bender

Friedrich Bossert

Hans J Ahr

Gu/ Nter Thomas

Hans-Jurgen Ahr

Thomas Gunter

Walter Hu/ Bsch

For the treatment of lipoproteinaemia and arteriosclerosis, the new disubstituted pyridines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl or heteroaryl,

Polysubstituted pyridines useful for treating lipoproteinanaemia and

Disubstituted pyridines

Novel compounds for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis of the formula ##STR1## in which A, B, D and E can have varied meanings,

Substituted pyridines heptenoic acid derivatives, useful for treating

Intermediate imino-substituted pyridines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl,

Certain intermediate imino-substituted pyridines

Substituted pyridyl-dihydroxy-heptenoic acid of the formula ##STR1## and its salts, if desired in an isomeric form, have a superior inhibitory action on HMG-CoA reductase and thus bring about a surprisingly good lowering of the cholesterol content in the blood.

Substituted pyridyl-dihydroxy-heptenoic acid and its salts

For the treatment of lipoproteinaemia and arteriosclerosis, the polysubstituted pridines of the formula ##STR1## in which R.sup.1 is optionally substituted furyl or thienyl,

7-[(2,6-dialkyl-4-furyl or

7-(polysubstituted pyridyl)-hept-6-endates useful for treating

For inhibiting HMG-CoA reductase and cholesterol synthesis, the novel 2-pyridones and pyrid-2-thiones of the formula ##STR1## in which A is optionally substituted aryl or heterocyclic,

Substituted 2-pyridones and pyrid-2-thiones compounds

HMG-COA reductase-inhibiting compounds of the formula ##STR1## in which X represents a group of the formula --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--,

HMG-COA reductase-inhibiting substituted amino-pyridines

Substituted pyrido(2,3-d) pyrimidines of the formula: ##STR1## useful as intermediates for the preparation of MMG-CoA reductase inhibitors.

Substituted pyrido (2,3-d) pyrimidines as intermediates

New substituted pyrido(2,3-d)pyrimidines of the formula ##STR1## can be prepared by reduction of corresponding pyrido(2,3-d)-pyrimidines which are substituted by a ketone radical, and subsequent hydrolysis, cyclization or hydrogenation. The new compounds can be used to inhibit HMG-CoA reductase.

HMG-CoA reductase inhibiting substituted pryido (2,3-d) pyrimidines

HMG-CoA reductase-inhibiting imino-substituted pyridines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl,

HMG-COA reductase-inhibiting imino-substituted pyridines

Inhibitors of 3-hydrooxy-3-methyl-glutarylcoenzyme A reductase which are 1,8-naphthyridines of the formula ##STR1## in which A

Substituted 1,8-naphthyridines and their use in medicaments

Inhibiting HMG-CoA reductase with novel substituted 2-pyridones and

Substituted hydroxylamines of the formula ##STR1## in which R.sup.1 stands for an aromatic or heterocyclic radical, are especially useful in the treatment of hyperlipoproteinaemia, lipoproteinaemia and atherosclerosis.

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Duesseldorf, Germany

Dieter Petzinna