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Bruker Analytik Gmbh

Robert-koch Institut

Bruker Daltonik Gmbh

Dieter Naumann

Peter Lasch

Thomas Maier

Jens Boβmeyer

Harald Labischinski

Jens Bossmeyer

Elizabeth Baldauf

Maren Stämmler

Janina Kneipp

Michael Beekes

The invention relates to methods for the mass spectrometric analysis of microbes, in particular to a transfer method of microbes that are required to be identified from agar plates onto mass spectrometric sample supports and their preparation for ionization by matrix-assisted laser desorption (MALDI). Microbes from microcolonies which have grown on the agar plates after a culture time of only six to eight hours are transferred with a high transfer yield onto contact surfaces of suitable size by direct contact and cell disrupted on the contact surface; the released proteins are prepared with matrix material on the contact surface as MALDI samples. The ionization by matrix-assisted laser desorption also takes place on the contact surface.

Analysis of microbes by MALDI mass spectrometry

A method for diagnosing TSE-induced pathologic changes in tissues including the steps of: (a) directing infrared radiation to a tissue sample with pathologic changes caused by TSE, recording its spectral characteristics after irradiation and (b) comparing and classifying the infrared spectra thus obtained with a reference database containing infrared spectra of TSE-infected tissues and non-infected tissues.

Method for diagnosing TSE-induced changes in tissues using infrared spectroscopy

Method for the rapid detection of microorganisms in samples

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Berlin, Germany

Dieter Naumann