Hoffmann-la Roche Inc.

Eth Zuerich

Eth Zurich

F. Hoffmann-la Roche Ag

Dieter Muri

Luca Claudio Gobbi

Matthias Koerner

Henner Knust

Edilio Borroni

Michael Honer

Bjoern Bartels

Simon Mensah Ametamey

Uwe Grether

Philipp Cueni

Julian Kretz

Ahmed Haider Wahauib

The present invention relates to a compound of formula (I) wherein R, R, and Rare defined as in the description and in the claims. The compound of formula (I) can be used as a radiolabeled ligand.

Radiolabeled cannabinoid receptor 2 ligand

The invention relates to small molecule imaging tools, specifically compounds of formula II and to pharmaceutically acceptable acid addition salts thereof, wherein R-Rhave any of the values defined in the specification.

2-hetaryl imidazol[1,2-a]pyridine derivatives

A process for preparing the compound of formula I comprising:a) coupling a compound of formula 2 wherein a leaving group O&#x2014;SO&#x2014;R is selected from the triflate group, the tosylate group, the mesylate group, the besylate group, the nosylate group or the brosylate group,with a suitable boronic acid, a trifluoroborate or a boronic acid esterunder argon condition and in the presence of a catalyst and a base in a suitable solvent and then isolating the product as an acid addition saltto afford the compound of formula Ia andb) converting the acid addition salt of formula Iawherein the acid HX comprises suitable organic or inorganic acids into the compound of formula I by treatment with at least a stoichiometric equivalent of a suitable base.

Process for preparation of 2-(6-nitropyridin-3-yl)-9H-dipyrido[2,3-b;3',4&#x2032;-d]pyrrole

The present invention relates to compounds that may be used for binding and imaging tau aggregates and related beta-sheet aggregates including, besides others, beta-amyloid aggregates or alpha-synuclein aggregates.

Diazacarbazole derivatives as tau-PET-ligands

The invention relates to small molecule imaging tools.

Imaging methods using 2-hetaryl imidazol[1,2-a]pyridine derivatives

The invention relates to compounds of formula I: and to pharmaceutically acceptable acid addition salts thereof, wherein R-R, R, and Rhave any of the values defined in the specification. The compounds are suitable as imaging tools.

2-phenyl or 2-hetaryl imidazol[1,2-a]pyridine derivatives

The present invention relates to compounds that may be used for binding and imaging tau aggregates and related beta-sheet aggregates including, for example, beta-amyloid aggregates or alpha-synuclein aggregates.

Imidazo[1,2-a]pyridin-7-amine

The present invention relates to compounds of general formula wherein R is hydrogen, halogen, lower alkyl substituted by halogen or lower alkoxy; The compounds are suitable as imaging tool, which will improve diagnosis by identifying potential patients with excess of tau aggregates in the brain, which may be likely to develop Alzheimer's disease.

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Basel, Switzerland

Dieter Muri