The General Hospital Corporation

Palomar Medicaltechnologies, Inc.

Blossom Innovations, LLC

Other

The Gneral Hospital Corporation

Dieter Manstein

R Rox Anderson

Henry Hin Lee Chan

Vincent Zuo

Gregory B Altshuler

William G Austen

Joseph Ting

William A Farinelli

Andrei V Erofeev

Henry Zenzie

James G Burke, Iii

Michael R Hamblin

Lilit Garibyan

Andrew J Radl

Michael Z Smirnov

Kachiu Lee

Seyed Reza Monazami Miralipour

Oge Onwudiwe

Jayant D Bhawalkar

Ilya Yaroslavsky

Stefan A Carp

Richard Rox Anderson

Michael Smotrich

Henry Hl Chan

Amir Y Sajjadi

Sergey B Biruchinsky

Michael Evers

Nunciada Salma

Henry H L Chan

Henry Hin Chan

Systems and methods for a medical device configured to provide cooling to a tissue region are provided. The medical device may be configured to noninvasively or invasively cool the tissue region to a predetermined operating temperature via a two-phase heat transfer process.

Systems and methods for thermal treatment of tissue

An exemplary treatment system can be provided which can include a laser system configured to emit at least one laser beam, and an optical system configured to focus the laser beam(s) to a focal region at a selected distance from a surface of a tissue. The focal region can be configured to illuminate at least a portion of a target. The optical system can cause an irradiation energy transferred to the focal region of the laser beam(s) to (i) generate a plasma in a first region of the tissue adjacent to the target, and (ii) avoid a generation of a plasma in a second region of the tissue. The optical system has a numerical aperture that is in the range of about 0.5 to about 0.9. An exemplary method can also be provided to control such treatment system.

Method and apparatus for selective treatment of biological tissue

Systems and methods for a medical device configured to provide cooling to a tissue region are provided. The medical device may be configured to noninvasively cool the tissue region to a predetermined operating temperature via a two-phase heat transfer process. In some aspects, the medical device can be configured to be in communication with a vacuum to provide a suction to the medical device. In some aspects, the medical device can be adapted to a medical device to noninvasively cool the tissue region near a fractional treatment area.

Described are methods for inducing browning of adipose tissue. More specifically, the present disclosure relates generally to methods for inducing browning of adipose tissue remote to the treatment location. The methods can include at least a first treatment and a second treatment, wherein the treatments comprise applying a cooling element to a local adipose tissue deposit, wherein the cooling element cools the local adipose tissue deposit to a temperature of between 0° C. to 30° C. for a period of time sufficient to induce browning of adipose tissue in one or more areas of the subject's body remote to the local adipose tissue deposit.

Localized cooling to induce browning of adipose tissue

Exemplary embodiments of a method, device, and apparatus for positioning an apparatus on a location of a tissue. For example, a substantially rigid film over an area of tissue to be treated can be provided. The film can include a positioning arrangement that facilitates a particular spatial engagement with the apparatus. The exemplary method can further include applying a portion of the film to a portion of a surface of the tissue and positioning the apparatus at the location by the engagement of the film to the apparatus using the feature of the film.

Method and apparatus for skin stabilization and positioning

Cosmetic method and apparatus are provided that can provide cooling and/or freezing of skin tissue proximal to the skin surface to generate an appearance of lightening or reduced pigmentation in the skin. The skin can be cooled to a temperature of less than about &#x2212;5 degrees Celsius for a duration of about one minute or less, using a cooled surface that is at least 3 cm in width. A cooling arrangement can be provided to provide controlled heat removal from the skin tissue being treated. A sensor can optionally be provided to detect freezing of tissue proximal to the cooled surface.

Method and apparatus for cryogenic treatment of skin tissue

The present invention relates to methods for use in the selective disruption of lipid-rich cells by controlled cooling. The present invention further relates to a device for use in carrying out the methods for selective disruption of lipid-rich cells by controlled cooling.

Methods and devices for selective disruption of fatty tissue by controlled cooling

Exemplary embodiments of an apparatus can be provided for obtaining portions or samples of tissue from a target region of a biological tissue. One or more needles can be provided that have a small internal diameter, e.g., about 1 mm or less, and the needles can be configured to extract the tissue portions when the needles are inserted into and withdrawn from the tissue. Windows and/or markings can be provided on the wall of the needles to facilitate access to the sample. The needles can be provided in an enclosure, and an actuator can be provided to direct the needles into the tissue and/or withdraw them. A plurality of tissue portions having known relative locations in the target region can be obtained, and extraction of the tissue portions can be well-tolerated by the tissue as compared with conventional punch biopsies or the like.

Apparatus and method for tissue biopsy

Exemplary embodiments of method and apparatus are provided for resurfacing of skin that includes formation of a plurality of small holes, e.g., having widths less than about 1 mm or 0.5 mm. For example, such small holes can be produced using a mechanical apparatus that includes one or more abrading elements provided at the end of one or more rotating shafts, thus avoiding generation of thermal damage as occurs with conventional laser resurfacing procedures and devices. The holes thus formed can be well-tolerated by the skin, and may exhibit shorter healing times and less swelling than conventional resurfacing procedures. The fractional surface coverage of the holes can be between about 0.1 and 0.7, or between about 0.2 and 0.5. The method and apparatus can produce cosmetic improvements in the skin appearance by eliciting a healing response.

Method and apparatus for discontinuous dermabrasion

A treatment system can include a channel generation system configured to expose an infected region of a target tissue with a laser beam traveling along an optical axis and focused at a focal volume located in or adjacent to the target tissue. The laser beam can have a wavelength ranging from about 100 nm to about 400 nm. The laser beam can be configured to generate at least a first channel in the infected region. The treatment system can also include a detection system configured to detect a first radiation generated by one or more of (i) the target tissue, (ii) a fungi coupled to the infected region in the target tissue, and (iii) an adjacent tissue located proximal to the target tissue as a result of interaction with the laser beam. The treatment system can also include a delivery system configured to deposit an active treatment agent in the at least first channel.

Therapeutic laser system and method

Cosmetic method and apparatus are provided that can provide cooling and/or freezing of skin tissue proximal to the skin surface to generate an appearance of lightening or reduced pigmentation in the skin. The skin can be cooled to a temperature of less than about &#x2212;5 degrees Celsius for a duration of about one minute or less, using a plurality of cooled contact surfaces, each having a width between about 2 mm and about 20 mm. A cooling arrangement can be provided to provide controlled heat removal from the skin tissue being treated. A sensor can optionally be provided to detect freezing of tissue proximal to the cooled surfaces.

The present disclosure provides systems and methods for characterizing and monitoring biological material. In one aspect, a method for characterizing biological material includes acquiring optical data associated with a biological material, and analyzing the optical data to determine optical properties of the biological tissue. The method also includes determining, using the optical properties, phase information corresponding to the biological material, and generating a report characterizing the biological tissue using at least the phase information.

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Boston, MA, United States of America

Dieter Manstein