Merck Patent Gmbh

Merck Patent Gesellschaft MIT Beschrankter Haftung

Daicel Chemical Industries, Ltd.

Tecan Trading Ag

Merck Kgaa

Daicel Corporation

Merck Patent Gesellschaft MIT Beschraenkter Haftung

Dieter Lubda

Michael Schulte

Mengyao Zheng

Nikolaus Ingenhoven

Christoph Saal

Karin Cabrera

Nicole Di Gallo

Guenter Moddelmog

Tatsushi Murakami

Gudrun Birk

Anja-Nadine Knuettel

Alexander Kraus

Egbert Mueller

Akihiro Nakanishi

Alessandro Elia

Klaus Unger

Karl-Siegfried Boos

Finn Bauer

Robertus Hendriks

Michael Schulz

Friedhelm Eisenbeiss

Hans-Dieter Harders

Gerhard Wieland

Roberto Ognibene

Thorsten Wedel

Ulrich Lang

Benjamin Peters

Klaus Kreher

Karin Cabrera Perez

Andreas Meudt

Willi Neuroth

Karl Siegfried Boos

Tanino Scaramuzza

Axel Delp

Kristina Czerny

Andreas Walfort

Edith Dicks

Gisela Schwinn

Hans-Leonhard Ohrem

Harald Benk

Melina Decker

Harald Muessig

Zöfre Bayram-Hahn

Charles Roderick McIlwrick

Michael Schleehahn

Olivier Ludemann-Hombourger

Charles Mcllwrick Roderick

Shawn Kucera

Friedhelm Eisenbeiß

Sandra Erika Bernhardt

Melanie Mechthild Breidung

Vanessa Witt

Lars Friedrich

The present invention relates to the use of spray-dried sorbitol, such as Parteck&#xae; SI, as plasticizer for polymer containing compositions processed by (hot) melt extrusion. Due to its improved properties, achieved by its special manufacturing process (spray drying), this direct compressible excipient shows more additional benefits than the same substance in crystalline state.

Hot melt extrusion composition using direct compressible excipient as plasticizer

An extrudable polyvinyl alcohol (PVA) powder with improved flowability containing particles of PVA, which has been cryo-milled, and which has dparticle sizes in the range of 45 to 1400 &#x3bc;m; or which has a particle size distribution of d=20&#xb1;10 &#x3bc;m, d=30&#xb1;10 &#x3bc;m, d=70&#xb1;10 &#x3bc;m, d=200&#xb1;30 &#x3bc;m, and d=300&#xb1;30 &#x3bc;m; and a powdery composition for the preparation of pharmaceutical formulations which contains the polyvinyl alcohol homogeneously mixed with at least one active pharmaceutical ingredient (API); and a process for producing a solid pharmaceutical dosage form by extruding or forming a homogeneous melt of a mixture of ingredients containing the powdered polyvinyl alcohol and at least one active pharmaceutical ingredient (API), and forming a powder or a molded form.

Particle size and distribution of polymer for melt extrusion application

The present invention relates to compacted glycine granules, where at least 75% of the granules have a particle size of above 0.7 mm, and to a process for the preparation and use of granules of this type.

Glycine particles

The present invention relates to the use of an amino sugar as plasticizer in formulations comprising a polymer as carrier for active ingredients, in particular for compositions which are intensively mixed by treatment in a melt extrusion and then formulated by suitable post-treatment.

Use of an amino sugar as plasticizer

The present invention relates to novel pharmaceutical formulations which have controlled, delayed release of active ingredient, and to a process for the preparation of such formulations. The invention additionally relates to the use of these novel pharmaceutical administration forms as medicaments for the treatment of diseases which require delayed release of the active ingredient, such as hypertension, or asthmatic diseases.

Formulation having controlled, delayed release of active ingredient

The present invention relates to a process for the production of monolithic separating columns using monolithic moldings whose diameter is reduced by grinding, and to separating columns having improved separation efficiency produced in this way, and to the use thereof.

Production of monolithic separating columns

This invention provides a separating agent for optical isomers, which has high asymmetry recognition ability and can be used particularly at a high flow rate when used for the separation of the optical isomers, and a separation column for optical isomers having the same. This invention provides: a separating agent for optical isomers which is used for separation of optical isomers in a sample comprising the optical isomers, which is comprising a monolithic inorganic type carrier having a meso pore formed on an inner wall surface of a specific macropore, and a polysaccharide or a polysaccharide derivative supported on the monolithic inorganic type carrier, wherein the meso pore has a pore size of 6 to 100 nm; and a separation column for optical isomers in which the separating agent for optical isomers is held in a column tube.

Separating agent for optical isomers and separation column for optical isomers

The present invention relates to inorganic monolithic mouldings whose surface is coated with physi- or chemisorbed organic polymers, and to processes for the production of materials of this type. The materials according to the invention are highly suitable as sorbents for chromatography, in particular for high pressure liquid chromatography of biological materials.

Inorganic monolithic mouldings coated with organic polymers

The invention relates to a device () for processing samples (), comprising a body () with a collecting chamber (), which can be connected with a pump () for aspirating, or dispensing fluids and that acts on this collecting chamber, a separating chamber () adjoining the collecting chamber () for the solid phase extraction and elution of organic, or inorganic particles () separated from these samples (), and an opening () for releasing these particles (). The device in accordance with the invention relates to individual pipette tips, as well as to SPE microplates, and is distinguished in that the device () comprises a capillary (), which is connected with the collecting chamber (), or with the body (), and has a packing () for the solid phase extraction of organic, or inorganic particles () separated from these samples () and is used as a separating chamber (). In accordance with the invention, the package () can be adapted to the chemical-physical nature of the organic, or inorganic particles () to be extracted, as well as to a defined minimum volume.

Device for processing samples, use of the device, and method for producing the device

The invention relates to the use of gelation moulds made from hydrophobicized glass tubes for the production of monolithic mouldings as sorbents for chromatography.

Process for producing an inorganic monolithic molding

The invention relates to a process for the production of chromatography columns or capillaries containing sorbents of monolithic mouldings which can remain directly in their gelation mould after production. This is achieved by the process according to the invention, in which the gelation mould is repeatedly filled with the monomer sol.

Method for producing monolithic chromatography columns

The invention relates to monolithic sorbents with a casing of fiber-reinforced plastic. Through the use of fiber-reinforced plastic having a viscosity of between 40 and 100 ml/10 min by the MVI method, the casing can be applied to the moulding leaving just a small dead space and has adequate mechanical stability.

Monolithic sorbents with fibre-reinforced plastic coating

The invention relates to use of monolithic sorbents for preparative separation processes, specially for processes according to the simulated moving bed (SMB) principle.

Use of monolithic sorbents for preparative chromatographic separation

Polymerisable polyamide derivatives

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Bensheim, Germany

Dieter Lubda