Novartis Ag

Ciba-geigy Corporation

Ciba Vision Corporation

Commonwealth Scientific and Industrial Research Organisation

Ciba Specialty Chemicals Corporation

Other

Centre Suisse D'electronique Et De Microtechnique Sa

Dieter Lohmann

Peter Chabrecek

Angelika Maria Domschke

Jens Hopken

Lynn Cook Winterton

Qin Liu

Richard Carlton Baron

Arthur Ho

Gordon Francis Meijs

Judy Smith Riffle

Paul Clement Nicolson

Bronwyn Glenice Laycock

Klaus H Schindhelm

Wilson Leonard Terry, Jr

Deborah Sweeney

John Court

Eric Papaspiliotopoulos

Jurgen Vogt

Hans Jorg Griesser

Gerd Greber

Jens H&ouml;pken

Thomas Hirt

J&ouml;rg Leukel

Hans Jorge Griesser

Troy Vernon Holland

Frank Bachmann

Roland Darms

Hanspeter Fischer

Siegfried Wyler

Jacalyn Marie Schremmer

Diethelm Bitzer

Christian d'Hondt

Werner Fory

Martin Roth

Ronald Christopher Chatelier

Kurt Dietliker

Marcus Baumann

Donald Richard Randell

Ernst Neuenschwander

Paul Zientek

Richard Dappen

Hans Jörg Griesser

Liming Dai

Sheng Li

Yongxing Qiu

Karl F Mueller

Robert A Falk

John Martin Lally

Werner Foery

Jürgen Vogt

Hans Sigrist

Markus Streiff

Ellen Marie Ajello

Peter Furrer

Hans J&ouml;rg Griesser

Guenter Rist

Ju/ Rgen Kaschig

Jörg Leukel

Hynek Biedermann

Yann Chevolot

Hans-J&ouml;rg Mathieu

Jose Martins

David Crout

Wolfgang Peter Meier

Eric Papspiliotopoulos

Jens Höpken

Rudolf Duthaler

Klaus Schindhelm

A method for making a silicone hydrogel contact lens is provided. In one embodiment, a prepolymer mixture is polymerized in a lens mold in an atmosphere having less than about 10000 ppm oxygen to form a silicone hydrogel contact lens suitable for extended wear as characterized by producing less than 10% corneal swelling after a period of continuous wear of 7 days including normal sleep periods. In one embodiment, the prepolymer mixture comprises at least one oxyperm material containing hydrophilic groups, wherein the at least one oxyperm material is a siloxane-containing macromer or monomer, at least one ionperm material, and a cross-linking agent. In certain embodiments, the polymerization of the prepolymer mixture may be carried out in an atmosphere having less than about 1000 ppm oxygen.

Extended wear ophthalmic lens

A method for making a silicone hydrogel contact lens is provided. In one embodiment, a prepolymer mixture is polymerized in a lens mold in an atmosphere having less than about 10000 ppm oxygen to form a silicone hydrogel contact lens suitable for extended wear as characterized by producing less than 10% corneal swelling after a period of continuous wear of 7 days including normal sleep periods. In one embodiment, the prepolymer mixture comprises at least one oxyperm material containing hydrophilic groups, wherein the at least one oxyperm material is a siloxane-containing macromer or monomer, at least one ionoperm material, and a cross-linking agent. In certain embodiments, the polymerization of the prepolymer mixture may be carried out in an atmosphere having less than about 1000 ppm oxygen.

An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. In one embodiment, an ophthalmic lens is a copolymerization product of at least one oxyperm, at least one ionoperm, and a crosslinker. In one embodiment, a lens has a tensile modulus of less than about 3.0 MPa, yet in another embodiment, the tensile modulus is between about 0.5 to about 1.5 MPa.

The invention relates to novel crosslinkable copolymers of formula wherein the variables are as defined in the claims. The copolymers of the invention are especially useful for the manufacture of biomedical moldings, for example ophthalmic moldings such as in particular contact lenses.

Amphiphilic block copolymers

Organic compounds

An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

The invention relates to novel crosslinkable copolymers of formula wherein the variables are as defined in the claims. The copolymers of the invention are especially useful for the manufacture of biomedical molding, for example ophthalmic moldings such as in particular contact lenses.

The invention is directed to a composite material, especially a biomedical device, e.g. an ophthalmic device, preferably a contact lens, with one or more wettable surfaces capable of holding a continuous layer of aqueous fluid thereon which composite material comprises a bulk material and a hydrophilic coating characterized in that the hydrophilic coating consists of a carbohydrate attached covalently to reactive groups at the surface of the bulk material, either directly or via functional groups of an oligofunctional compound, said oligofunctional compound in turn having functional groups being capable of reacting with said reactive groups at the surface of the bulk material and with the carbohydrate, wherein said reactive groups are either inherently (a priori) present in the bulk material or wherein said reactive groups have been attached to the surface of the bulk material by a plasma surface preparation, as well as to a process of manufacture of such a composite material.

Multilayer materials

The invention relates to a process for coating a material surface, comprising the steps of: The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.

Method for modifying the surface of biomedical articles

Bottle-brush type coatings with entangled hydrophilic polymer

Process for the modification of surface

The invention relates to novel composite materials comprising (a) an inorganic or organic bulk material having covalently bound to its surface initiator moieties for radical polymerization; and (b) a hydrophilic surface coating obtainable by applying one or more different ethylenically unsaturated hydrophilic macromonomers of formula (1) as outlined in the claims to the bulk material surface provided with the initiator radicals and polymerizing said macromonomers. The composite materials of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.

Organic articles

Growing community of inventors

Münchenstein, Switzerland

Dieter Lohmann