Basf Aktiengesellschaft

Abbott Laboratories Corporation

Dieter Herr

Volker Laux

Achim Moeller

Jörg Breitenbach

Jörg Rosenberg

Robert Heger

Karl-Heinz Geiss

Lothar Daum

Thomas Doerper

F J Van Der Woude

Benito Yard

The present invention relates to formulations based on at least one heparin, glycosaminoglycan or heparinoid and on a formulation base with a lipid component and a polymer component. The use of this formulation as drug form for oral administration of at least one heparin, glycosaminoglycan or heparinoid, and also a process for producing the formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as drug form, advantageously using melt extrusion, are described. The lipid component advantageously has active ingredient-promoting properties, while the polymer component is soluble or swellable. At least parts of the lipid component are embedded in a polymer matrix, preferably in the form of a molecular dispersion. The formulations can form emulsions in water or aqueous liquids.

Formulation based on heparin, glycosaminoglycan or heparinoid, use of the formulation and the formulation base

The invention relates to the use of polysulfated glycosaminoglycans having a sulfur content of at least 12.5% for producing pharmaceutical preparations for inhibiting the &ggr;-interferon-induced upregulation of the MHC Class I and MHC Class II proteins and ICAM-1. The invention furthermore relates to organoprotective solutions comprising polysulfated glycosaminoglycans and to a process for the ex-vivo protection of transplant organs.

Organoprotective solutions

Polysulfated heparins are used for the preparation of drugs for the prophylaxis and therapy of diseases caused by retroviruses.

Polysulfated heparins for treating diseases caused by retroviruses

An enterally absorbable heparin or heparinoid preparation contains a non-ionic surfactant.

Increasing the enteral absorbability of heparin or heparinoids

Growing community of inventors

Altrip, Germany

Dieter Herr