Autifony Therapeutics Limited

Glaxo Group Limited

Replidyne, Inc.

Glaxogrouplimited

Smithkline Beecham Corporation

Dieter Hamprecht

Fabrizio Micheli

Giuseppe Alvaro

Agostino Marasco

Luca Tarsi

Silvia Terreni

Giorgio Bonanomi

Anne Decor

Charles Large

Gabriella Gentile

Stefano Fontana

Paolo Dambruoso

Giovanna Tedesco

Simona Tommasi

Luca Arista

Anne Dècor

Romano Di Fabio

Anna Checchia

Federica Damiani

Richard Lewis Jarvest

Andrew Keith Forrest

John Michael Berge

Anna Maria Capelli

Elettra Fazzolari

Mohammad Tadayyon

Daniele Andreotti

David Richard Witty

Martin C Jones

Adolfo Prandi

Sergio Melotto

Kamal A Al-Barazanji

Sula Anne Armstrong

Anne Décor

Caterina Mazzoni

Christian Heidbreder

Tadataka Yamada

Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders. 

Triazoles as Kv3 inhibitors

The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.

Imidazolidinedione derivatives

Triazoles as KV3 inhibitors

The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizophrenia, substance abuse disorders, sleep disorders or epilepsy.

The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders. 

Hydantoin derivatives as KV3 inhibitors

The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizophrenia, substance abuse disorders, sleep disorders or epilepsy. 

The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt thereof: wherein

[object Object]

Compounds of formula (I) or a salt thereof are disclosed: wherein Ris pyrazolyl substituted by two or three substituents independently selected from halogen, Calkyl and haloCalkyl; Ris hydrogen or methyl; and Ris quinolinyl, oxazolyl or phenyl, each of which is optionally substituted by one or two halogen, Calkyl or haloCalkyl. Processes for preparation and uses of the compounds in medicine, for example for the treatment of schizophrenia or drug dependency, are also disclosed.

7-pyrazolylbenzazepines having affinity for D3 receptor

Compounds of formula (I) wherein A is a 5 or 6 membered heteroaromatic ring or a 5 or 6 membered heterocyclic ring, and which are useful for treating mental disorders such as schizophrenia are set out herein.

Compounds having affinity for dopamine D3 receptor and uses thereof

The present invention relates to novel compounds of formula (I) or pharmaceutically acceptable salt thereof: processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine Dreceptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, premature ejaculation or cognition impairment.

3-(1,2,4-triazol-3-ylalkyl) azabicyclo (3.1.0) hexane derivatives as modulators of dopamine D3 receptors

Azabicyclo (3.1.0) hexane derivatives useful as modulators of dopamine D3 receptors

Growing community of inventors

Verona, Italy

Dieter Hamprecht