Hoffmann-La Roche Inc.

Arpida Ag

Acino Pharma Ag

Dieter Gillessen

Kaspar Burri

Arnold Trzeciak

Sorana Greiveldinger-Poenaru

Khalid Islam

Arthur M Felix

Johannes A Meienhofer

Rolf Studer

William Lergier

Juergen Jaeger

The invention concerns a stable aqueous pharmaceutical composition comprising 5-[(2RS)-2-cyclopropyl-7,8-dimethoxy-2H-1-benzopyran-5-ylmethyl]-pyrimidine-2,4-diamine in form of the water soluble methanesulfonic acid salt, a physiological sodium chloride solution, ethanol and Povidone 12 PF, the liquid having a pH of over and above 4.8, but not higher than 5.2, and wherein the oxygen amount is controlled to be 0.8 ppm or less; which can be sterilized by filtration and/or by heated treatment, stored for longer time periods and which can be use for bolus injection or diluted for i.v. infusion.

Aqueous pharmaceutical formulation

The invention relates to new benzofuran derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as anti-infectives.

Benzofuran derivatives and their use in the treatment of microbial infections

The invention relates to new benzofuran derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds, and especially their use as anti-infectives.

Selected benzofuran derivatives

The invention relates to novel benzofuran derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as anti-infectives.

Benzofuran derivatives and their use as antibacterial agents

An improved solution phase synthesis of thymosin .alpha..sub.1 and proceeding through novel intermediates is disclosed.

Synthesis of thymosin .alpha..sub.1

An improved solution phase synthesis of thymosin .alpha..sub.1 and desacetyl thymosin .alpha..sub.1 with t-Boc side chain protection and proceeding through novel intermediates is disclosed.

Synthesis of thymosin .alpha..sub.1 and desacetyl thymosin .alpha..sub.1

Method for the determination of an amino benzoic acid or aminosulphonic acid in urine, plasma or serum. The method consists essentially in reacting a urine, plasma or serum sample with a compound of the 4-phenyl-spiro[furan-2(3H)1'-phthalan]-3,3'-dione type or with a compound of the 2-methoxy-2,4-diphenyl-3(2H)-furanone type or with o-phthaldialdehyde and subsequently carrying out a photometric measurement.

Method for the determination of an amino or aminosulphonic acid

This disclosure relates to L-pyroglutamyl-L-histidyl-L-prolyl-beta-alaninamide and acid addition salts thereof as anti-depressant agents.

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Pratteln, Switzerland

Dieter Gillessen