Hoechst Aktiengesellschaft

Dieter Duwel

Reinhard Kirsch

Heinz Loewe

Josef Urbanietz

Gerhard Kretzschmar

Hans Rochling

Peter Hammann

Manfred Rosner

Kurt Hartel

Hilmar Mildenberger

Werner Bonin

Susanne Grabley

Gerhard Seibert

Klaus Kuhlein

Gerhard Salbeck

Gerhard Wohner

Rudiger Marquardt

Hartmut Voelskow

Carlo Giani

Theophil Hornykiewytsch

Gunter Karl Dransch, Deceased

By Annelise Wiesenhutter, Heiress

Gunter Kratt

Johanna Mathilde Flersheim, Heiress

The invention relates to a composition which contains at least one active substance, a wax, a weighting agent and optionally a sugar, sugar alcohol, cellulose ether or a polyethylene glycol, an active substance release system built up from this composition, a process for its preparation and its use in veterinary medicine and animal nutrition.

Preparation for the controlled release of active substances which are

Pyrimidinetrione derivatives, processes for their preparation, agents containing them and their use as agents for combating pests. Compounds of the formula I, tautomeric forms thereof of the formula Ia, stereoisomers thereof and the mixtures of these forms ##STR1## wherein R.sup.1 and R.sup.2 denote unsubstituted or substituted alkyl, alkenyl, alkynyl; alkoxy, alkylsulfonyl, alkylcarbonyl or cyano or optionally substituted phenyl, phenylsulfonyl or phenylcarbonyl,

Pyrimidinetrione derivatives, agents containing them and their use as

The invention relates to elaiophylin derivatives of the formulae (I), (I'), (III) and (III') ##STR1## in which the C.dbd.C double bonds in the 2,3 and 4,5 position may also be hydrogenated and in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and X have the meanings indicated. The invention furthermore relates to a process for the preparation of these elaiophylin derivatives, and the use thereof as pharmaceuticals, in particular as anthelmintic pharmaceuticals.

Basic cleavage products of elaiophylin and elaiophylin derivatives and

The invention relates to elaiophyline derivatives of the formula I ##STR1## in which R.sup.1 and R.sup.1' are identical or different and represent a radical of the formula II/or III ##STR2## in which R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.7 have the meanings given. The invention furthermore relates to a process for the preparation of these elaiophyline derivatives and also the use of the lattere as medicaments, in particular as anthelmintically acting medicaments.

Elaiophyline derivatives, compositions containing them and the use

New phenylsulfonyloxybenzimidazolecarbamates of the formula ##STR1## are described, as are processes for their preparation. The new compounds have anthelmintic activity, including, in particular, against liver flukes.

Substituted phenylsulfonyloxybenzimidazolecarbamates and anthelmintic

New benzenesulfonic esters of the formula I ##STR1## and a process for their preparation are described. The new compounds are active against helminths and can thus be used as agents to counter worms in humans and animals.

Substituted benzenesulfonic esters and their use as medicaments for

New monocarboxylates of phenylguanidinesulfonic acid esters and a process for their manufacture are described. They are effective as medicaments against helminths and liver flukes when administered orally or parenterally.

Monocarboxylates of phenylguanidinesulfonic acid esters, a process for

2-Carbalkoxyamino-benzimidazolyl-5(6)-sulfonic acid phenyl esters are disclosed as well as a process for their manufacture. The new compounds have valuable chemotherapeutic properties and are suitable for combating diseases caused by parasites in humans and animals, such as helminths and liver flukes.

3,4-Diaminophenyl sulfonic acid esters

Substituted phenylguanidines are disclosed as well as a process for their manufacture. The said compounds are active against helminths and liver flukes.

Substituted phenylguanidines and process for their manufacture

3-Carbalkoxyamino-1H-2,1,4-benzothiadiazine derivatives are disclosed as well as a process for their manufacture. The compounds are suitable for combatting helminths and especially gastrointestinal Strongylides and liver flukes.

3-Carbalkoxyamino-1H-2,1,4-benzothiadiazine derivatives

Anthelmintically active basically substituted 2-carbalkoxy-amino-benzimidazolyl-5(6)-phenyl ethers and -ketones are disclosed as well as a process for preparing them. The compounds are chemotherapeutics having a particular activity against ankylostomes, other helminths as well as liver fluke.

Anthelmintically active basically substituted

The present invention relates to triazinobenzimidazoles and to a process for their preparation. The compounds are chemotherapeutics and are suitable for combating parasitary diseases in humans and animals; they are especially active against nematodes.

Substituted triazino-benzimidazoles

Anthelmintically active 2-carbalkoxyamino benzimidazolyl-5(6)-sulfonic

2-Carbalkoxyamino-5(6)-phenyl sulfonyloxy benzimidazoles are disclosed as well as a process for their manufacture. The new compounds are valuable chemotherapeutic agents and are suitable for combating diseases caused by parasites in humans and animals, such as helminths and liver flukes.

Growing community of inventors

Hofheim am Taunus, Germany

Dieter Duwel