Rohm Gmbh

Rohm Gmbh Chemische Fabrik

Dieter Dreher

Klaus Lehmann

Werner Siol

Hubert Rauch

Harry Goetz

Kurt H Bauer

Gerhard Markert

Wolfgang Weisbrod

Hermann Osterwald

Aqueous dispersions of a water-swellable but water-insoluble polymer formed between a quaternary ammonium monomer and a nonionic monomer; methods for making such dispersions by dispersing said copolymers, in the form of a powder, in water; methods for coating pharmaceutical cores, powders, or granules with such dispersions; and coated pharmaceutical products made by such methods.

Aqueous coating dispersions

A method for coating solid pharmaceutical formulations, comprising coating said solid formulation with an aqueous fluid, film forming coating medium comprising a dissolved polymer prepared from acrylic and/or methacrylic monomers having a side group containing a tertiary amine substituent, wherein the amine nitrogen atom is converted to the ammonium salt form; and then drying said coated film.

Method for coating pharmaceutical formulations

Coated pharmaceutical dosage forms which are resistant to gastric juice and release their active ingredient rapidly at a predetermined pH value in the range from pH 5 to pH 8 are obtained in accordance with the invention by coating pharmaceutical dosage forms with an aqueous dispersion containing dispersed latex particles of a first polymer which contains carboxyl groups and is water soluble between pH 5 and pH 8 and of a second water insoluble film forming polymer, in a weight ratio between 60:40 and 5:95.

Coating for pharmaceutical dosage forms

What are disclosed are methods for dispersing a powdered salt-forming synthetic resin in water in the presence of an agent forming a salt with said resin, methods for coating pharmaceutical dosage forms with a dispersion made by such a method, and powdered mixtures of a salt forming resin and salt forming agent for dispersion in water.

Method for coating medicaments

Coating materials for pharmaceutical dosage forms contain, besides the conventional liquid or solid additives for pharmaceutical coatings, a binder comprising a synthetic polymer, prepared by emulsion polymerization, having 5 to 100% by weight of units derived from monomers of the formula ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl group, R.sub.2 is an alkylene or aralkylene group having at least 3 carbon atoms in the chain between the amino nitrogen and the ester oxygen atom of which at least one is tertiary or quaternary, and R.sub.3 and R.sub.4 are lower alkyl radicals or together with the amino-nitrogen atom form a heteroaliphatic ring, and, optionally, additional comonomer units.

Pharmaceutical coating materials soluble or swellable in gastric juice

What are disclosed are methods for making a suspension suitable for use as a coating agent for medicaments by suspending a powder of certain vinyl copolymers in an aqueous solution or suspension of a plasticizer therefor, methods for converting such a suspension of copolymer in plasticizer into a film-forming solution or other extensively homogeneous phase, such suspensions and the film-forming conversion products thereof, and methods for coating medicaments with such suspensions and film-forming conversion products.

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Darmstadt, Germany

Dieter Dreher