Merck Patent Gmbh

Merck Patent Gesellschaft MIT Beschrankter Haftung

Merck Patent Gesellschaft

Merck Patent Gesellschaft MIT Beschraenkter Haftung

Ciba Specialty Chemicals Corporation

Ciba-geigy Corporation

Marck Patent Gmbh

Dieter Dorsch

Werner Mederski

Oliver Schadt

Frank Stieber

Andree Blaukat

Christos Tsaklakidis

Norbert Beier

Johannes Gleitz

Bertram Cezanne

Klaus-Otto Minck

Guenter Hoelzemann

Hans-Peter Buchstaller

Rolf Gericke

Ingeborg Lues

Rudolf Eidenschink

Pierre Schelling

Eike Poetsch

Alfred Jonczyk

Manfred Baumgarth

Frank Zenke

Christiane Amendt

Lars Thore Burgdorf

Christina Esdar

Claus J Schmitges

Maria Christadler

Hanns Wurziger

Christian Sirrenberg

Manfred Kohler

Ulrich Finkenzeller

Bernhard Rieger

Ekkehard Bartmann

Hans A Kurmeier

Volker Reiffenrath

Georg Weber

Herbert Plach

Bernhard Scheuble

Gerd Bartoszyk

Joachim Gante

Hans-Michael Eggenweiler

David Coates

Joachim Krause

Reinhard Hittich

Christoph Seyfried

Andreas Wachtler

Simon Greenfield

Kai Schiemann

Markus Klein

Rudolf Gottschlich

Gérard Moinet

Andreas Bathe

Volker Meyer

Henning Böttcher

Mathias Osswald

Margarita Wucherer-Plietker

Thomas J J Mueller

Eugen Merkul

Claudia Wilm

Christopher Barnes

Horst Juraszyk

Jorg Ohngemach

Paul Czodrowski

Ansgar Wegener

Gerhard Greber

Christoph Van Amsterdam

Christoph Saal

Florian Lang

Clemens Kuehn

Axel Becker

Cristina Donini

Guido Melzer

Sabine Bernotat-Danielowski

Mathilde Muzerelle

Jurgen Gehlhaus

Oliver Poeschke

Gnuni Karapetyan

Hans Ludwig Hirsch

Konrad Dorfner

Melanie Schultz

Henning Boettcher

Claus P Herz

Heinz-Hermann Bokel

Michael Busch

Soheila Anzali

Wilfried Rautenberg

Dirk Finsinger

Birgitta Leuthner

Klaus Otto Minck

Jeyaprakashnarayanan Seenisamy

Matthias Grell

Mireille Krier

Ulrich Graedler

Graham Smith

David Bruge

Juergen Harting

Claus Fittschen

Klaus P Stahl

Michael Arlt

Hans Michael Eggenweiler

Michel Calderini

Heino Finkelmann

Compounds of the formula I are provided. These compounds can inhibit c-Kit kinase and can be employed for the treatment of cancer.

Indazolyl-isoxazole derivatives for the treatment of diseases such as cancer

Compounds of the formula I in which X, X, X, X, R, R, R, Q and Y have the meanings indicated in claimare inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.

Quinolin-2-one derivatives

Compounds of the formula I in which X, X, X, X, R, R, R, Q and Y have the meanings indicated in Claimare inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.

Compounds of the formula I in which Z, W, Q, R and Y have the meanings indicated in claim, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

1,4-dicarbonyl-piperidyl derivatives

Compounds of the formula I in which Rand Rhave the meanings indicated in Claim, are inhibitors of ATR, and can be employed for the treatment of diseases such as cancer.

Tricyclic heterocylic derivatives

Compounds of the formula I in which W, R, Rand Rhave the meanings indicated in claim, are inhibitors of ALK1, AL2 and ALK5, and can be employed for the treatment of diseases such as cancer.

3-(1H-benzimidazol-2-yl)-1H-pyridin-2-one derivatives

Compounds of the formula I in which R-Rand Z have the meanings indicated in Claim, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

Oxoquinazolinyl-butanamide derivatives

Compounds of the formula I in which X, Y, Q, M, Qand B have the meanings indicated in Claim, are inhibitors of GCN2, and can be employed, inter alia, for the treatment of cancer.

Macrocycles as kinase inhibitors

Compounds of the formula I in which Rand Rhave the meanings indicated in claim, are inhibitors of GCN2, and can be employed, inter alia, for the treatment of cancer.

Triazolo[4,5-d]pyrimidine derivatives

Compounds of the formula I in which W, X and Y have the meanings indicated in Claim, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

Heterocyclyl-butanamide derivatives

Compounds of the formula I in which R-Rhave the meanings indicated in Claimare inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

Piperidine urea derivatives

Compounds of the formula I in which R, X and n have the meanings indicated in Claim, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

Phthalazine derivatives

Compounds of the formula (I) in which R, R, Rand Rhave the meanings indicated in Claim, are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumors.

7-azaindole derivatives

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Ober-Ramstadt, Germany

Dieter Dorsch