Hoffmann-la Roche Inc.

Chemisch Pharmazeutische Forschungsgesellschaft M.b.h.

Cl Pharma Aktiengesellschaft

Laevosan-gesellschaft Mbh & Co Kg

Chemie Linz Aktiengesellschaft

Laevosan-gesellschaft M.b.h.

Dritte Patentportfolio Beteiligungsgesellschaft Mbh &co. Kg

Chemisch Pharmazeutische Forschungsgesellschaft

Ebewe Arzneimittel Gesellschaft M.b.h.

Chemish Pharmazeutische Forschungsgesellschaft M.b.h.

Leavoson-gesellschaft M.b.h. & Co. Kg

Chemie Linz Akteingesellschaft

Chemi Linz Aktiengesellschaft

Chemie-linz Aktiengesellschaet

Dieter Binder

Otto Hromatka

Franz Rovenszky

Paul Zeller

Rudolf Pfister

Hubert P Ferber

Josef Weinberger

Gerhard Greier

Franz Rovensky

Michael Pyerin

Joseph Hellerbach

Karsten Schror

Friedrich Hillebrand

Christian Noe

Norman Brunner

Eva Binder, Legal Representative

Andreas Koch

The invention relates to the use of lornoxicam or analogues thereof which inhibit cyclo-oxygenase 1 and cyclo-oxygenase 2 (COX 1 and COX 2), cannot penetrate the blood-brain barrier under physiological conditions, and reduce the prostaglandin E2-induced induction of the amyloid-precursor-protein (APP), for producing a pharmaceutical composition for the treatment or prevention of Alzheimer's disease or arteriosclerosis.

Use of oxicam compounds

Thienothiazine derivatives of the formula ##STR1## are provided. These derivatives are useful for the treatment of inflammation and pain.

Thienithiazine derivatives

Thienothiazine derivatives of the formula ##STR1## in which X denotes a single bond, a straight chain or branched carbon chain having 1-12 C-atoms in the chain, it being possible for this chain to contain one or more double or triple bonds and/or two or more heteroatoms, Y denotes a single bond, and R denotes a monocyclic or polycyclic, optionally partly hydrogenated aryl, heteroaryl, arlyoxy, arylaza, heteroarylaza, arylthio or heteroarylthio radical which can optionally be substituted by lower alkyl, mono- or poyhalogenated lower alkyl, perfluorinated lower alkyl, alkoxy or halogen, and their use.

Thienothiazine derivatives and their use

Thiophene-2-carboxylic acid derivatives

Novel imidazole-5-carboxylic acid acylals of the general formula ##STR1## in which R.sub.1 denotes an optionally unsaturated, straight-chain alkyl group having 1-6 carbon atoms, R.sub.2 denotes hydrogen, chlorine, bromine, iodine or CF.sub.3 and R.sub.3 denotes C.sub.1 -C.sub.10 -alkyl, C.sub.3 -C.sub.7 -cycloalkyl or benzyl, and their pharmaceutically tolerable salts.

Acylals of imidazole-5-carboxylic acid derivatives, and their use as

Tetrazole derivatives of the formula ##STR1## in which R.sub.1 denotes a saturated or unsaturated, straight-chain or branched (C.sub.1 -C.sub.6) alkyl radical and R.sub.2 denotes methyl or ethyl, and their pharmaceutically usable salts.

New tetrazole derivatives, process for their preparation and their use

Thienyloxyalkylamine derivatives, process for their preparation and

Sulphamoylathiophenes of the formula ##STR1## in which Y denotes O or S,

Sulphamoylthiophenes, a process for their preparation

Thienopyran derivatives of the general formula ##STR1## in which the radial ##STR2## denotes one of the formulae ##STR3## R denotes hydrogen or a radical --CN, --CHO, --CH.dbd.NOH, --CONH.sub.2 or --COOR.sub.1,

Thienopyran derivatives, their use for treating hypertension and asthma

1-(3-(2-hydroxy-3-alkylaminopropoxy)-2-thienyl)-3-phenyl-1-propanones represented by formula (I) ##STR1## wherein R.sub.1 and R.sub.2 each represent a lower alkyl group, and a process for the preparation of the same. The compounds of the present invention are useful in the treatment of cardiac arrhythmias.

1-(3-(2-hydroxy-3-alkylaminopropoxy)-2-thienyl)-3-phenyl-1-propanones

The invention relates to novel thieno-(3',4'-4,5)imidazo(2,1-b)thiazole derivatives of the formula ##STR1## in which R.sub.1 denotes hydrogen, halogen or CF.sub.3 and

Thieno (3',4'-4,5)imidazo(2,1-b)thiazole derivatives, a process for

The invention relates to a novel basic-substituted 5-halo-thienoisothiazol-3(2H)-one 1,1-dioxide of the formula ##STR1## in which R.sub.1 denotes hydrogen, (C.sub.1 -C.sub.4)-alkyl or halogen,

Novel basic-substituted 5-halo-thienoisothiazol-3(2H)-one 1,1-dioxides,

The invention relates to new enol ethers of 6-chloro-4-hydroxy-2-methyl-N-(2-pyridyl)-2H-thieno(2,3-e)-1,2- thiazine-3-carboxamide 1,1-dioxide of the formula ##STR1## in which R denotes (C.sub.1 -C.sub.6)-alkyl, (C.sub.5 -C.sub.7)-cycloalkyl or benzyl, and a process for their preparation. The new compounds have an antiinflammatory activity and are suitable for the treatment of rheumatism.

Enol ethers of

The invention relates to novel 2-thienyloxyacetic acid derivatives of the general formula ##STR1## in which R denotes a phenyl or thienyl group which is optionally mono- or polysubstituted by halogen, trifluoromethyl or C.sub.1 -C.sub.4 alkyl, and pharmaceutically usable salts thereof, a process for the preparation of these compounds and their use for the treatment of thromboses, inflammations, high blood pressure, apoplexy and angina pectoris.

Novel 2-thienyloxyacetic acid derivatives, a process for their

Substituted isoxazoles of the formula ##STR1## in which R.sub.1 denotes C.sub.1 -C.sub.4 alkyl, R.sub.2 denotes hydrogen, C.sub.1 -C.sub.4 alkyl chlorine or bromine, R.sub.3 and R.sub.4, which are the same or different are hydrogen or C.sub.1 -C.sub.4 alkyl, but not both hydrogen and n denotes the interger 6, 7, or 8. The novel ocmpounds have a pronounced antiviral action and can be employed for the treatment and prophylaxis of virus diseases.

Growing community of inventors

Vienna, Austria

Dieter Binder