Behringwerke Aktiengesellschaft

Aventis Behring Gmbh

Zlb Behring Gmbh

Dieter Bernhardt

Albrecht Gr&ouml;ner

Thomas Weimer

Albrecht Groener

Joachim Hilfenhaus

Thomas Nowak

Albrecht Groner

The invention relates to the use of acridine or acridine derivatives, preferably in combination with benzalkonium chloride, for the inactivation of enveloped or nonenveloped viruses. The process according to the invention is preferably carried out in the presence of proteins whose biological activity is substantially retained.

Process for the inactivation of viruses with the aid of acridine derivatives

Methods for growing circoviruses, in particular porcine circoviruses, which are obtained from an infected cell culture after one or more passages in cultures of porcine, bovine or human cells are described. When the porcine circoviruses grow, a cytopathogenic effect occurs in the cell culture.

Method for growing circoviruses

A process and an agent for the sanitization of tissues or cell cultures and also of materials and equipment which can be contaminated with viruses are described. For sanitization, a solution of a substituted phenol or of a substituted phenol ether is employed here which as substituents carries one or two saturated or unsaturated hydrocarbon radicals which in each case can have up to 4 carbon atoms.

Process and agent for sanitation of contaminations caused by viruses

The invention relates to the removal of viruses from aqueous solutions, as a rule protein solutions, by ultrafiltration. This entails the viruses to be removed being increased in size by incubation with a high molecular weight receptor binding thereto, preferably a specific antibody, so that, on the one hand, the separation effect is improved and, on the other hand, a larger pore diameter which can now be chosen for the filters used also makes it possible for smaller viruses to be separated from larger protein molecules present in protein solutions, and, where appropriate, the filtration rate is increased.

Removal of viruses from protein solutions by ultrafiltration

Cell line and processes for the replicating rabies viruses and detecting

A bovine ovary cell line (FROv), a process for its preparation, and its use for replicating viruses, are described.

Bovine ovary cell line (FROV) for virus replication

A solution containing antigen and adjuvant for eliciting an immune response. The adjuvant comprises zinc hydroxide or iron hydroxide in an amount sufficient to enhance the immune response elicited by the antigen. A process for preparation of such a solution is also provided.

Solutions containing antigen and zinc hydroxide or iron hydroxide as an

A process for treating antigen solutions with an adjuvant is described, in which process a zinc hydroxide/calcium hydroxide gel and, where appropriate, additionally a lecithin and, where appropriate, additionally a polyalphaolefin is added to the antigen solution.

Growing community of inventors

Cölbe, Germany

Dieter Bernhardt