University of California

Optical Networks, Inc.

Diego R Yankelevich

Laura Marcu

Julien Bec

Nicholas Lawrence Abbott

Richard A Hill

Andre Knoesen

Scott A Hamilton

Gary Bjorklund

Dinglong Ma

Dimitris Gorpas

Benjamin E Sherlock

The disclosed embodiments relate to multimodal imaging system, comprising: a fiber-coupled fluorescence imaging system, which operates based on ultra-violet (UV) excitation light; and a fiber-coupled optical coherence tomography (OCT) imaging system. The multimodal imaging system also includes a fiber optic interface comprising a single optical fiber, which facilitates light delivery to a sample-of-interest and collection of returned optical signals for both the fluorescence imaging system and the OCT imaging system. During operation of the system, the single optical fiber carries both UV light and coherent infrared light through two concentric light-guiding regions, thereby facilitating generation of precisely co-registered optical data from the fluorescence imaging system and the OCT imaging system.

Fiber-based multimodal biophotonic imaging and spectroscopy system

A multimodal intravascular catheter system includes a catheter with an optical channel and an electrical channel. A distal end of the catheter includes an optical element and an ultrasonic transducer, which are oriented orthogonally to a rotational axis of the catheter. A motor drive unit (MDU) is coupled to a proximal end of the catheter and includes a drive motor to rotate the catheter. The optical channel directs light from a pulsed UV laser source to the optical element, and returns an optical fluorescence signal from the optical element. A photodetector converts the returned optical fluorescence signal into an electrical fluorescence signal. An intravascular ultrasound (IVUS) processor is coupled to the ultrasonic transducer through the electrical channel, wherein the IVUS processor generates a drive signal for the ultrasound transducer, and processes echo information returned from the ultrasound transducer. Finally, a digitizer samples the electrical fluorescence signal and associated echo information.

Single catheter system that provides both intravascular ultrasound and fluorescence lifetime imaging

The disclosed embodiments relate to a system that displays an image of the characteristics of the biological tissue. During operation, the system enables a user to illuminate a measurement location in an area of interest on the biological tissue by manipulating a point measurement probe, wherein the point measurement probe delivers both an excitation beam and an overlapping aiming beam that is visible to a camera. Next, the system obtains fluorescence information from a fluorescence signal emitted from the measurement location in response to the excitation beam. The system then captures an image of the area of interest using the camera and identifies a portion of the image that corresponds to the measurement location by identifying a location illuminated by the aiming beam. Finally, the system generates an overlay image by overlaying the fluorescence information onto the portion of the image that corresponds to the measurement location, and then displays the overlay image to a user.

Facilitating real-time visualization of tissue features derived from optical signals

A coplanar waveguide polymeric in-line fiber construct (CPW-PILF) formed on an optic half coupler substrate base or D-fiber wherein the surface is polished down through the cladding on the optical fiber so as to form an evanescent coupling region on the surface. Co-planar, spaced-apart electrodes are deposited on the surface with their gap aligned over the coupling region, and an electro-optic (EO) polymeric waveguide is deposited over the electrodes and between the electrode gap. Light transmitted thorough the optical fiber is evanescently coupled to said waveguide and modulated by a signal applied to the electrodes. Alternatively, the waveguide is deposited on the surface of the substrate and the electrodes are deposited over the waveguide.

In-line polymeric construct for modulators, filters, switches and other

Growing community of inventors

Davis, CA, United States of America

Diego R Yankelevich