Dutch Renewable Energy B.v.

Pronova Laboratories B.v.

Diede Hendrik Paul Klever

Hubert Clemens Pellikaan

Rolf Lourens Visser

Maurice Rombout

An applicator for applying cryogenic fluid to a treatment area is described, the applicator comprising: a reservoir () configured to contain a cryogenic fluid comprising a gas phase (G) and a liquid phase (L). A nozzle () extends from a proximal end arranged in fluid communication with the reservoir () to an open distal end () for application of fluid to a treatment area. An actuatable valve is provided to selectively allow a flow of cryogenic fluid from the reservoir () through the distal end of the nozzle (). A spacer () extends distally beyond the distal end () of the nozzle (), the spacer () comprising a skin contacting surface () at its distal end. A porous material () is provided between the distal end () of the nozzle (), at least between the open end of the nozzle and the skin contacting surface of the spacer.

Cryogenic applicator

The present invention relates to a dispensing system for spraying a liquid/gas mixture, the system including a dispenser and a holder in which the dispenser is held, the dispenser including a container that is adapted for holding therein a liquid phase and a gas phase that is at a pressure of 2 bar or greater and is in direct contact with the liquid phase. The dispensing system may be used in a first orientation and a second orientation, wherein the ratio of liquid to gas in the sprayed mixture is different depending on the orientation of the system during spraying.

Dispensing system

The invention relates to a dispensing system for use in cryogenic skin treatment that is capable of targeted delivery of a cryogen at a high rate, thereby achieving rapid freezing of targeted skin tissue. The dispensing system of the present invention uses a cryogen that contains dimethyl ether and is designed to deliver the cryogen in an accurate and very effective manner.

Dispensing system for use in cryogenic skin treatment

The present invention relates to a nebulizer, such as a spray can, for the topical application of a liquid and/or solid to a surface. The nebulizer is characterized by a valve comprising a mixing chamber designed for forming a colloidal mixture comprising a dispersed phase consisting of a liquid and/or a solid substance and a continuous phase consisting of a propellant gas before delivering the colloidal mixture to the nozzle. The invention also relates to a method for the topical cooling of the skin of a person or animal. In addition, the invention relates to various other uses of the device.

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Amsterdam, Netherlands

Diede Hendrik Paul Klever