Affitech Research As

Spinchip Diagnostics As

Didrik Paus

Sergej Kiprijanov

Remko Griep

Stig Morten Borch

Torgeir Hamsund

Rolf Jahren

Lavinia Diana Cicortas Gunnarsson

Sebastian Stenmark

Jenny Margareta Karlsson

Erik L Meyer

Håvard Kristiansen

Odd Martin Staal

Steven Hill

Ole-Andreas Kavli

The present invention provides antibodies which bind to an epitope in the extracellular domain of human CC chemokine receptor 4 (CCR4) and which are capable of inhibiting the binding of macrophage-derived chemokine (MDC) and/or thymus and activation regulated chemokine (TARC) to CCR4. Also provided are inter alia immunoconjugates and compositions comprising such antibodies and methods and uses involving such antibodies, particularly in the medical and diagnostic fields.

Antibodies

Disclosed are antibodies that bind to Epithelial Cell Adhesion Molecule (EpCAM) and display certain advantages over known antibodies which bind to EpCAM, for example, the antibodies of the invention show good affinity, good cross-reactivity profiles and excellent ADCC and CDCC activity. Antibodies comprising specific heavy and light chain CDRs are disclosed. The invention thus relates to these antibodies and all uses thereof, in particular in the treatment of cancer. The present invention thus provides new antibody-based compositions, methods and combined protocols for treating cancer. Advantageous immunoconjugate compositions and methods using the new anti-EpCAM antibodies are also provided.

Anti-EpCAM antibodies

Growing community of inventors

Oslo, Norway

Didrik Paus