Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

UniversitÉde Strasbourg

Universitè De Montpellier

Institut National De Recherche Pour L'agriculture

Institut National De Recherche Pour L'agriculture, L'alimentation Et L'environnement

Immupharma France Sa

Didier Rognan

Jean-Charles Schwartz

Jeanne-Marie Lecomte

Camille-Georges Wermuth

Bruno Giros

Pierre Sokoloff

Jean Valmier

Fabrice Garrido

Gerard Lambeau

Martine Schmitt

Marie-Pascale Martres

Jean-Philippe Leyris

Didier Lereclus

Nalini Rama Rao

Gilles Guichard

Pascal Muller

Gersande Lena

Eric Boilard

Embodiments of the present disclosure relate to methods of screening and optionally designing compounds as inhibitors of Mfd (Mutation Frequency Decline), such compounds being useful for the treatment of bacterial infections. Embodiments of the methods include culturing pathogenic bacteria expressing functional Mfd with various concentrations of 1 mM or less, incubating the cultures with and without nitric oxide stress conditions, evaluating bacterial survival in each of the cultures, and calculating the concentration of the molecule required to decrease by 50% the survival rate of the bacteria (IC50) by comparing the cfu of the untreated cultures and cultures following nitric oxide stress.

Method of screening antibacterial compounds as inhibitor of Mfd

The invention pertains to novel FLT3 receptor antagonists of general formula (1). The compounds are useful for the treatment or the prevention of pain disorders, cancer and autoimmune diseases. 

FLT3 receptor antagonists

The new naphthamide derivatives according to the invention are characterized in that they correspond to the general formula (I), ##STR1## where X: represents either a hydrogen atom, or a chlorine or bromine atom, or an amino or aminoalkyl group, an aminosulphamoyl group, a sulphur-containing group such as thiocyanate, alkylthio, alkylsulphinyl or alkylsulphonyl, or a methoxy group, or a nitro group, or a cyano group, or an electron-attracting group;

Naphthamide derivatives

Growing community of inventors

Bernardswiller, France

Didier Rognan