Pierre Fabre Medicament

Didier Junquero

Elisabeth Dupont-Passelaigue

Karine Valeille

Isabelle Leroy

Yves Rival

Bruno Le Grand

Samuel Mialhe

Nicolas Monjotin

Michel Perez

Jean-Pierre Rieu

Marie Lamothe

Jean-Marie Autin

Andre Delhon

Thierry Clerc

André Delhon

Jean-Francedillaois Patoiseau

Philippe Oms

Jean-François Patoiseau

Elisabeth Dupont-passelaigue

The present invention relates to the use of PAR1 antagonists, in particular of vorapaxar, of atopaxar and of 3-(2-chlorophenyl)-1-[4-(4-fluorobenzyl)piperazin-1-yl]propenone, or a pharmaceutically acceptable salt thereof, for preventing and/or treating pelvi-perineal functional pathological conditions, and more particularly painful bladder syndrome.

Use of PAR-1 antagonists for preventing and/or treating pelvi-perineal functional pathological conditions

The object of the present invention is benzothiazine derivatives having the capability of inhibiting 11&#x3b2;-HSD1 not only at an enzymatic level but also at a cell level. The compounds of the present invention are of general formula (I). Wherein notably Rrepresents a hydrogen or OR1 represents an ester or an ether. Rrepresents a naphthyl or a 1,2,3,4-tetrahydro-naphthalene or a biphenyl or phenyl pyridine or a substituted phenyl. Rrepresents a methyl or ethyl; Rand R'represent a hydrogen. 

Derivatives of benzothiazines, preparation thereof and application thereof as drugs

The present invention relates to compounds having general formula I characterized in that  

Nitrogen heterocycle derivatives, preparation thereof and application thereof in human therapeutics

The present invention concerns compounds of general formula (I) characterized in that (formula 1) wherein, in particular: &#x2014;Rrepresents one or more groups such as: trifluoromethyl, halogen such as F, Cl, &#x2014;when n=m=1, W represents CH then Y represents oxygen, &#x2014;U represents: &#x2022;either &#x2014;(C&#x2550;O)CHNH&#x2014; and is branched at position 4 of pyridazinone, then R2 represents H, &#x2022;or &#x2014;(C&#x2550;O)NH&#x2014; and U is branched at positions (4), (5) or (6) of pyridazinone, then R2 represents H, &#x2014;R3 represents a hydrogen or methyl and the addition salts with pharmaceutically acceptable bases and acids and the different isomers, and their mixtures in any proportion for use as SCD-1 enzyme inhibitors for the treatment of obesity, type-2 diabetes and lipid disorders. 

Derivatives of 2H pyridazin-3-ones, their preparation and their use as SCD-1 inhibitors

The present invention relates to derivatives of general formula I wherein: &#x2014;W represents nitrogen, &#x2014;Rrepresents: &#x2022;a hydrogen or a linear or branched C-Calkyl radical or, &#x2022;a C-Calkyl radical substituted with groups such as trifluoromethyl, nitrile, hydroxy, C-Calcoxy, C-Calkoxyalkoxy, indolyl, thiophenyl, oxothiophenyl, C-CN-alkylcarbamoyl groups or, &#x2022;a phenyl or pyridyl or naphthyl, or thiophenyl group optionally substituted with one or more groups such as halogen atoms, nitro, nitrile, trifluoromethyl, vinyl, methylsulfanyl, linear branched C-Calkyl, linear or branched C-Calkoxy groups, &#x2022;a C2-oxocycloalkyl radical&#x2014;Rrepresents a methyl or heptyl, -m, n are equal to 1, &#x2014;V represents CH, &#x2014;X&#x2014;Y represents &#x2014;N&#x2014; (C&#x2550;O)&#x2014;, &#x2014;CH&#x2014;O&#x2014;, &#x2014;Z represents a phenyl group substituted with one or more trifluoromethyl groups, halogen atoms or linear C-Calkyl groups. 

Derivatives of triazines and uracils, their preparation and their application in human therapeutics

The invention relates to 3,5-dioxo-(2H,4H)-1,2,4-triazine compounds of formula I in which the variables are defined herein, as well as additive salts with pharmaceutically acceptable bases and the various enantiomers of compounds having asymmetrical carbons, as well as their mixtures in all proportions, including racemic mixtures in particular.

1,2,4-triazine derivatives, preparation and use thereof in human therapy

2,3,5-trimethyl-4-hydroxyanilide derivatives, preparation thereof and

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Castres, France

Didier Junquero