Centre National De La Recherche Scientifique

National Institute of Health and Medical Research

Trophy

Didier Gourier

Daniel Scherman

Jean-Marc Inglese

Bruno Viana

Sylvie M Bothorel

Serge Maitrejean

Philippe Barboux

Dominique Biava

Aurelie Bessiere

Michel Bessodes

Corinne Chaneac

Jean-Pierre Jolivet

Quentin Le Masne De Chermont

Fabienne Sylvie Pelle

Mathieu Rault

Thomas Maldiney

Laurent Binet

Cyrille Richard

Jean-Pierre Ponpon

Aurélie Bessiere

This invention relates to a method to manufacture a chip to detect the direct conversion of X-rays. It also relates to a direct conversion detector for X-rays using such a chip and dental radiology equipment using at least one such detector. The method to manufacture the wafer comprises a step for applying pressure () to a powdered polycrystalline semiconductor material and a step for heating (-) during a set time period. It comprises a preliminary step for providing an impurity level of at least 0.2% in the polycrystalline semiconductor material.

Method for manufacturing a sensor chip for the direct conversion of X-rays, a sensor for the direct conversion of X-rays and the dental radiology apparatus for using such a sensor

Multimodal optical and magnetic resonance imaging methods based on the use of persistent luminescence nanoparticles. Use of mesoporous persistent luminescence &#x3c;&#x3c;core-shell&#x3e;&#x3e; complexes for theranostic applications.

Persistent luminescence nanoparticles excitable in situ for in vivo optical imaging, in vivo multimodal optical&#x2014;MRI imaging, and theranostics

The invention relates to using persistent luminescence nanoparticles, functionalised if necessary, in the form of an diagnosis agent for an in vivo optical imaging. Said nanoparticles are preferably consist of a compound selected from a group comprising (1) silicates, aluminates, aluminosilicates, germanates, titanates, oxysulphides, phosphates and vanadates, wherein said compounds contain at least one type of metal oxide, (2) the sulphides comprise at least one metal ion selected from zinc, strontium and calcium, and (3) metal oxides, wherein said compounds is doped with at least one rare earth ion, and possibly with at least one transition metal ion. In a preferred embodiment, the diagnosis agent is used for an organism vascularization imaging. A method and kit for detecting or quantifying in vitro a substance of biological or chemical interest in a sample by using said pre-functionalised nanoparticles are also disclosed.

Persistent luminescence nanoparticles used in the form of a diagnosis agent for in vivo optical imaging

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Paris, France

Didier Gourier