Symyx Technologies, Inc.

Kodiak Sciences Inc.

Jsr Corporation

Didier G Benoit

Dominique Charmot

Stephen A Charles

Wayne To

Martin Sheringham Linsell

Gerrit Klaerner

Kenji Okamoto

James Bradley Aggen

Adam Luke Safir

Isao Nishimura

Han-Ting Chang

Yong Wang

Daniel Victor Perlroth

D Victor Perlroth

Li Song

Laura T Mazzola

Lane A Clizbe

Paul Mansky

Ralph B Nielsen

Miroslav Petro

Bernd Jandeleit

Xiaojian Huang

Victor D Perlroth

Lidia Mosyak

William Stuart Somers

Laura Lin

Marcelo Eduardo Piotti

Tetsuya Ishino

Akimasa Soyano

Justin Cohen

Srinivas Nomula

Linda J Zadik

Jeanne M Pratt

The present invention provides multi-armed high MW polymers containing hydrophilic groups conjugated to Factor VIII, and methods of preparing such polymers.

Factor VIII zwitterionic polymer conjugates

The present invention provides random copolymers containing zwitterions and one or more functional agents, and methods of preparing such random copolymers.

Multifunctional zwitterionic polymer conjugates

The invention provides a dual VEGF/PDGF antagonist comprising a VEGF antagonist linked to a PDGF antagonist. The VEGF antagonist is an antibody to a VEGF or VEGFR or is a VEGFR extracellular trap segment (i.e., a segment from the extracellular region of one or more VEGFR receptors that inhibits binding of at least one VEGFR to at least one VEGF). The PDGF antagonist is an antibody to a PDGF or PDGFR or is a PDGFR extracellular trap segment (i.e., segment from the extracellular region of one or more PDGFRs, which inhibits binding of at least one PDGFR and at least one PDGF). The dual antagonist is preferably conjugated to a half-life extending moiety, such as a HEMA-PC polymer. The dual antagonist is particularly useful for treating wet aged related macular degeneration.

Dual PDGF/VEGF antagonists

The present invention provides recombinant butyrylcholinesterase fusion proteins, including Fc fusion proteins and multi-armed high MW polymers containing hydrophilic groups conjugated to the fusion proteins, and methods of preparing such polymers.

Butyrylcholinesterase zwitterionic polymer conjugates

The present invention is directed to the preparation of photoresist polymers via living free radical polymerization techniques. Sterically bulky ester monomers are utilized as the polymerization components. Use of chain transfer agents is included in polymerization processing conditions. Cleavage of polymer terminal end groups that include a heteroatom are described.

Photoresist polymers

Photoresist polymer compositions

Synthesis of photoresist polymers

Controlled architecture polymers made preferably with acrylamide type monomers are prepared in living-type or semi-living-type free radical polymerizations, with the architecture preferably being other than linear, such as star, branched, grafted or hyper-branched. The controlled architecture polymers have high weight average molecular weights and low viscosities, which make they particularly useful in replaceable capillary electrophoresis separation media for biological molecules, such as DNA fragments.

Controlled-architecture polymers and use thereof as separation media

Sensors for determining the presence and concentration of biomolecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface modified with a hydrophobic polymer segment, attached to which is a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, which allows for controlled architecture polymers to modify the surface of the substrate, and the use of monomers possessing functional groups which do not require activation prior to probe attachment. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.

Polymer brushes for immobilizing molecules to a surface or substrate having improved stability

Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, and in particular the use of an iniferter initiator, which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.

Polymer brushes for immobilizing molecules to a surface and having water-soluble or water-dispersible segments therein and probes bonded thereto

Growing community of inventors

San Jose, CA, United States of America

Didier G Benoit