Universitéde Liége

Other

Université Libre De Bruxelles

F. Hoffmann-la Roche Ag

Aquilon Pharmaceuticals

Zimmermann Gerd

Hans-willi Krell

Richard Endele

Pierre Bartsch

Jean-michel Foidart

Didier Cataldo

Brigitte Evrard

Luc Delattre

Maes, Paul

Jean-Michel Foidart

Hans-Willi Krell

Gerd Zimmermann

Pascal De Tullio

Robert Kiss

Paul Maes

Didier Serteyn

Jacques Delarge

Véronique Mathieu

Philippe Neven

Agnes Noel

Agnès Noel

Veronique Mathieu

Natacha Rocks

Jean-Michel Foldart

Gilles Dufour

William Bigazzi

The present invention relates to novel and useful pharmaceutical compositions formulated with a cyclodextrin compound and a budesonide derivative for the treatment and/or prevention of pulmonary inflammatory disease. The present invention also relates to a novel and useful analytical technique for the detection and the quantification of HP-&#x3b2;-CD in solution. More specifically, the present invention relates to the use of a validated 1H NMR analysis for the detection and quantification of cyclodextrins directly in pharmaceutical formulations without any extraction or separation steps for liquid formulations.

Cyclodextrin and budesonide derivative compositions and methods

The invention provides the use of a cyclodextrin compound for the manufacturing of a medicament for the treatment or prevention of bronchial inflammatory diseases, particularly for asthma and chronic obstructive pulmonary disease (COPD).

Use of cyclodextrin for treatment and prevention of bronchial inflammatory diseases

The present invention relates to the medical field. In a first aspect the present invention relates to novel water soluble cyclodextrin-curcumin complexes having a pharmacological activity, in particular an anti-tumor and/or anti-inflammatory activity, and improved physico-chemical properties. In a second aspect, the present invention relates to a method for preparation of said water soluble curcumin derivatives. The invention further relates in a third aspect to a pharmaceutical composition comprising an effective amount of said water soluble curcumin derivatives. In a fourth aspect, the present invention concerns the use of said water soluble cucumin derivatives as a medicament and the use of said water soluble curcumin derivatives for the preparation of a medicament for the treatment of cancer and inflammatory diseases. In a fifth aspect, the present invention relates to the use of a pharmaceutical composition comprising said water soluble curcumin derivatives in the treatment of cancer and inflammatory diseases and to a new pharmaceutical composition comprising said water soluble curcumin derivatives.

Water soluble curcumin compositions for use in anti-cancer and anti-inflammatory therapy

A trioxopyrimidine-cyclodextrin complex formed of a trioxopyrimidine derivative or a salt thereof and a water-soluble cyclodextrin derivative has improved solubility.

Pharmaceutical compositions of pyrimidine-2,4,6-triones

The invention provides the use of a cyclodextrin compound for the manufacturing of a medicament for the treatment or prevention of bronchial inflammatory diseases, particularly for asthma.

Growing community of inventors

Olne, Belgium

Didier Cataldo