Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Commissariat a L'energie Atomique Et Aux Energies Alternatives

Université Grenoble Alpes

Université Joseph Fourier

The Joseph Fourier University of Grenoble

Commissariat À L'énergie Atomique Et Aux Énergies Alternatives

Didier Boturyn

Jean-Luc Coll

Pascal Dumy

Isabelle Texier-Nogues

Saioa Cobo

Guy Royal

Marie Favrot

Veronique Josserand

Marie-Christine Favrot

Eric Saint-Aman

Véronique Josserand

Catherine Ghezzi

Daniel Fagret

Laurent Riou

Disclosed are dihydropyrene derivatives, processes for preparing the same and their uses.

Dihydropyrene derivatives, processes for preparing the same and their uses

The invention concerns the field of molecular probe architecture for in vivo imaging. More particularly, the invention concerns molecular constructs providing an imaging function activable in intracellular environment. The inventive fluorescence probes enable in particular images of certain targeted tissues to be formed, while maintaining a low background noise level and, preferably, while obtaining at the targeted tissue, an imaging signal increasing in time.

Target vector with activable imaging function

A method for preparing a grafted homodetic cyclopeptide forming a framework that defines a grafted upper face and grafted lower face, including synthesizing a linear peptide from modified or unmodified amino acids, some of which carry orthogonal protective groups; intramolecular cyclizing the resulting protected linear peptide; substituting some or all of orthogonal protective groups with a protected precursor; and grafting at least one molecule of interest onto one and/or the other face of the framework via an oxime bond.

Synthesis and characterization of novel systems for guidance and vectorization of molecules of therapeutic interest towards target cells

Growing community of inventors

Grenoble, France

Didier Boturyn