Anamar Ab

Anamar Medical Ab

Nordic Bioscience A/s

Dick Heinegård

Pilar Lorenzo

Mikael Danfelter

Tore Saxne

Patrik Önnerfjord

Anna Johnson

Alexander Kvist

Emma Åhrman

Anders Aspberg

Johann Jakob Stubendorff

A method for detecting or monitoring the presence of protein fragments, cleaved at novel cleaving sites near the N-terminal part of the collagen IX alpha 1 chain, close to the C-terminal part of the NC4 domain, and at the COL3 domain close to the NC3 domain. Neoepitope antibodies against the neoepitopes were created by the cleavages and an epitope in the cleaved N-terminal part of the NC4 domain unique to collagen IX. A diagnostic kit and antibodies useful in carrying out such methods are also presented.

Diagnosis of collagen IX destruction

The present invention provides a new sensitive direct sandwich assay for determining the presence of COMP in a clinical sample. Two monoclonal antibodies directed against separate antigenic determinants of the COMP molecules are used in the assay. The invention also relates to three particularly advantageous monoclonal antibodies per se that are directed against human COMP. Cell cultures manufacturing these antibodies have been deposited according to the Budapest Treaty at Deutsche Sammlung von Mikroorganismen and Zellkulturen GmbH, and have been assigned accesion numbers DSM ACC2406, DSM ACC2408 and DSM ACC2418, respectively. A diagnostic kit comprising at least two of these monoclonal antibodies also constitute a part of the present invention.

Monoclonal antibodies for cartillage oligomeric matrix protein

The present invention comprises the use of chondroitin sulphate (CS-E) or an active fragment thereof for the treatment of diseases or conditions related to collagen fibril formation. Said compounds can be administrated either by oral, topical, injectable or by any other suitable route.

Use of chondroitin sulphate E (CS-E) for the treatment of diseases or conditions related to collagen fibril formation

Growing community of inventors

Lund, Sweden

Dick Heinegård