Hangzhou Minsheng Pharmaceutical Co. Ltd

Hangzhou Minsheng Pharmaceuticals Co., Ltd.

Purdue Pharmaceuticals Products L.p.

Hangzhou Minsheng Institutes for Pharma Research

Euro-celtique S.a.

Hangzhou Minsheng Pharm. Co., Ltd.

Dianwu Guo

Shulong Wang

Feiyu Feng

Lan Yang

Qiufu Ge

Yi Heng Chen

Yu Cheng Chen

Ximing Shen

Kai Tang

Binnan Huang

Zhenhua Liu

Zhonghua Peng

Jian Cai

Like Tang

Chunxia Wu

Tianjia Xu

Zhaoke Meng

Runan Mei

Yu Chen

Yi Chen

A class of quinazoline derivatives or pharmaceutically acceptable salts or solvates thereof with novel structures is provided; meanwhile, a pharmaceutical composition comprising a pharmaceutically effective amount of said quinazoline derivatives or pharmaceutically acceptable salts or solvates thereof, and pharmaceutically acceptable excipients or additives is also provided. By modifying and transforming the quinazoline and screening of the transformed compounds on the activity of tyrosine kinase inhibition, most of the compounds have been found to possess inhibitory activity against one or several of EGFR, VEGFR-2, c-erbB-2, c-erbB-4, c-met, tie-2, PDGFR, c-src, lck, Zap70 and fyn kinases. The present invention has the advantages of reasonable design, broad source of and easy access to the raw materials, simple and easy operation of the preparation methods, mild reaction conditions, high yield of the products and being beneficial for industrial-scale production.

Quinazoline derivative, composition having the derivative, and use of the derivative in preparing medicament

The present invention is directed to pharmaceutical compositions comprising: (a) a cyclopolysaccharide and (b) a compound of Formula (I) or its pharmaceutical acceptable salt: wherein X, X, Q, Z, and m are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these compositions.

Pharmaceutical compositions

The present invention provides a hypolipidemic composition comprising peony extract andextract, or comprising water coextract of peony and, the weight ratio of the peony extract toextract in the composition is between 0.5 and 19:1. The advantages of the hypolipidemic composition are: substantially decreasing triglyceride and cholesterol, while increasing high density lipoprotein. It suggested of a favourable prospect of application.

Hypolipidemic composition and its use

The present invention provides curcumol derivatives of the following formula (I) or pharmaceutical acceptable salts thereof:  

Curcumol derivatives, the compositions containing the said derivatives, and the use of the same in the manufacture of medicaments

The present invention relates to the diol intermediate of citalopram useful for treatment of depression, which is the crystal of free base of 3-hydroxylmethyl-4-[1-(4-fluorophenyl)-1-hydroxyl-4-(dimethylamino)]butylbenzonitrile and the method of crystallization thereof. The present invention has disclosed the method to prepare pure citalopram and its purified salts through crystallization of the described base; the optical resolution method of citalopram diol intermediate, the method to prepare S-citalopram and its purified salts by crystals mentioned above. The present invention has also disclosed the method to prepare citalopram and its purified salts, S-citalopram and its purified salts, as well as pharmaceutical formulation thereof obtained. Using methods of the present invention, the quality and yield of the product can be significantly improved, and the production cost of the medicinal material can be reduced.

Crystalline citalopram diol intermediate alkali

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Hangzhou, China

Dianwu Guo