Glaxo Group Limited

Glaxosmithkline LLC

Glaxosmithkline Intellectual Property Development Limited

Glaxosmithkline Intellectual Property (no.2) Limited

Diane Mary Coe

Stephen Allan Smith

Keith Biggadike

Brian Edgar Looker

Panayiotis Alexandrou Procopiou

Charlotte Jane Mitchell

Philip Charles Box

Naimisha Trivedi

Xiao Qing Lewell

Anthony William James Cooper

Stephen Barry Guntrip

Daniel Terence Tape

Michael John Monteith

Inderjit Singh Mann

Aurelie Cecile Champigny

Helene G Bazin-Lee

Deborah Needham

Rajnikant Patel

Dean David Edney

Rebecca Jane Moore

Abigail Halton

Julie Nicole Hamblin

Paul Spencer Jones

Mika Lindvall

Alison Judith Redgrave

Martin Redpath Johnson

David George Allen

Caroline Mary Cook

Christopher David Edlin

Duncan Stuart Holmes

David A Johnson

Michael D Dowle

Ian B Campbell

Linos Lazarides

Simon John Fawcett MacDonald

James Michael Woolven

Stefan Senger

Graham George Adam Inglis

Gordon G Weingarten

David House

Sadie Vile

Sebastien Andre Campos

Paul Martin Gore

Steven Leslie Sollis

Gianpaolo Bravi

John Edward Robinson

Philip Alan Skone

Iain McFarlane McLay

Graham George Inglis

Heather Anne Barnett

Simon John Fawcett Macdonald

Steven Philip Keeling

Haydn Terence Jones

Caroline Wilson

Ian Baxter Campbell

Gordon Gad Weingarten

Anthony William Cooper

Simon John Macdonald

Iain Mcfarlane Mclay

A compound of formula (1) Or a pharmaceutically acceptable salt and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases and conditions in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer and as vaccine adjuvants.

Cyclic di-nucleotides as modulators of STING

Compounds of formula (I) and salts thereof: wherein Ris hydrogen, methyl or &#x2014;(CH)OR, Ris methyl or &#x2014;(CH)OR, or Rand R, together with the nitrogen atom to which they are attached, are linked to form a 5- or 6-membered heterocyclyl wherein the 6-membered heterocyclyl is optionally substituted by two hydroxy substituents; Rand Rare each independently hydrogen or methyl; and n is an integer having a value of 5 or 6, are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment or prevention of various disorders, for example the treatment or prevention of allergic diseases and other inflammatory conditions, for example allergic rhinitis and asthma, infectious diseases and cancer, and may also be useful as vaccine adjuvants.

Pyrrolo[3,2-D]pyrimidine derivatives as inducers of human interferon

Compounds of formula (I): wherein Ris Calkylamino, Calkoxy, or Ccycloalkyloxy; m is an integer having a value of 3 to 6; n is an integer having a value of 0 to 4; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

6-amino-purin-8-one compounds

A compound of formula (I) or a pharmaceutically acceptable salt and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases and conditions in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.

Cyclic dinucleotides useful for the treatment of inter alia cancer

Compounds of formula (I) and salts thereof: wherein Ris n-Calkyl or CalkoxyCalkyl-, Ris halo, OH or Calkyl, m is an integer having a value of 4, 5, 6 or 7, n is an integer having a value of 0, 1, 2 or 3, and p is an integer having a value of 0, 1 or 2, are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions, for example allergic rhinitis and asthma, infectious diseases and cancer, and may also be useful as vaccine adjuvants.

Pyrazolopyrimidine compounds

Compounds of formula (I) and salts thereof: wherein Ris n-Calkyl or CalkoxyCalkyl-; Ris hydrogen or methyl; each Ris hydroxy, halo or n-Calkyl; m is an integer having a value of 2 to 4; n is an integer having a value of 0 to 3; and p is an integer having a value of 0 to 2, are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions, for example allergic rhinitis and asthma, infectious diseases and cancer, and may also be useful as vaccine adjuvants.

Pyrrolopyrimidines as therapeutic agents for the treatment of diseases

The present invention relates to Compounds of formula (I) and salts thereof: wherein Ris n-Calkyl; Ris hydrogen or methyl; Ris hydrogen or Calkyl, and m is an integer having a value of 0 to 3; are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions, for example allergic rhinitis and asthma, infectious diseases and cancer, and may also be useful as vaccine adjuvants.

The present invention relates to compounds of formula (I) and salts thereof: wherein Ris n-Calkyl; Ris hydrogen or methyl; Ris hydrogen or Calkyl, and m is an integer having a value of 1 to 4; are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions, for example allergic rhinitis and asthma, infectious diseases and cancer, and may also be useful as vaccine adjuvants.

Compounds

The present invention relates to compounds of formula (I): wherein Ris Calkylamino, Calkoxy, or Ccycloalkyloxy; m is an integer having a value of 3 to 6; n is an integer having a value of 0 to 4; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases

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Stevenage, United Kingdom

Diane Mary Coe