Sanofi Pasteur Inc.

Connaught Laboratories Limited

Diane M Gajewczyk

Michel Henri Klein

James Tartaglia

Benjamin Rovinski

Shi-Xian Cao

Fei-Long Yao

Roy Persson

Heather A Boux

Phillipe Moingeon

Anton Novak

A modulated immune response to an antigen is achieved by coadministering the antigen and a genetically-detoxifiedholotoxin, particularly one retaining its immunogenicity, to a host. The modulated immune response enables immunogenic compositions, including multivalent pediatric vaccines such as DTP, to be provided which produce a modulated immune response in the absence of extrinsic adjuvants such as alum. The adjuvanting effect achieved by the genetically-detoxifiedholotoxin enables at least the same level of adjuvanting effect to be achieved as previously attained by alum, without the undesirable side effects thereof.

Proteinaceous adjuvants

Vectors for DNA immunization against cervical cancer comprise a nucleic acid molecule encoding at least one non-toxic T-cell epitope of the E6 and/or E7 antigens of a strain of human papilloma virus (HPV) associated with cervical cancer, such as HPV-16, and a promoter operatively coupled to the nucleic acid molecule for expression of the nucleic acid molecule in a host to which the vector is administered.

Vectors for DNA immunization against cervical cancer

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Aurora, Canada

Diane M Gajewczyk