University of Connecticut

Seminis Vegetable Seeds, Inc.

Optoelectronics Systems Consulting, Inc."osci"

Diane J Burgess

Fotios Papadimitrakopoulos

Antonio P Costa

David M Webster

Faquir Chand Jain

Daniel H Grantham

Jeffrey T Koberstein

Donald L Kreutzer

Samuel Huang

Francis Moussy

Upkar Bhardwaj

Rajesh V Lalla

Tingting Li

Daniel H(deceased) Grantham

Antonio Costa

The present disclosure provides a system for the internal and external modification of nanoparticles in a continuous process. The system includes (a) a first inlet, (b) a second inlet, (c) a first pump in fluid communication with the first inlet, (d) a second pump in fluid communication with the second inlet, (e) a first flow meter positioned between the first pump and the first mixer, (f) a second flow meter positioned between the second pump and the first mixer, and (g) a mixing chamber in fluid communication with the first flow meter and the second flow meter, and (h) a first heat exchanger in fluid communication with the mixing chamber.

Continuous processing system and methods for internal and external modifications to nanoparticles

Compositions that include a bupivacaine salt are provided. The compositions may include bupivacaine linoleate, bupivacaine linolenate or bupivacaine laurate, at least one thermosensitive polymer, and at least one mucoadhesive or dermoadhesive agent. Also provided are methods for the treatment of an inflammatory or ulcerative condition with the disclosed compositions.

Long-acting local anesthetic formulation

The present disclosure provides systems and methods for the continuous production of liposomes. An example method includes (a) mixing a solution of lipid and organic solvent from one or more containers to create an organic solvent-lipid solution, (b) providing the organic solvent-lipid solution to a first inlet of an injection port at a first flow rate, wherein the first inlet is in fluid communication with a first conduit, (c) providing an aqueous solution to a second inlet of the injection port at a second flow rate, wherein the second inlet is influid communication with a second conduit, wherein the first conduit is positioned concentrically within the second conduit at an outlet of the injection port, and wherein the first conduit extends through the outlet of the injection port, and (d) mixing the organic lipid solution and the aqueous solution to create a plurality of liposomes.

Systems and methods for continuous manufacturing of liposomal drug formulations

Disclosed herein is an analyte sensing device capable of continuously monitoring metabolic levels of a plurality of analytes. The device comprises an external unit, which, for example, could be worn around the wrist like a wristwatch or could be incorporated into a cell phone or PDA device, and an implantable sensor platform that is suitable, for example, for implantation under the skin. The external device and the internal device are in wireless communication. In one embodiment, the external device and the internal device are operationally linked by a feedback system. In one embodiment, the internal device is encapsulated in a biocompatible coating capable of controlling the local tissue environment in order to prevent/minimize inflammation and fibrosis, promote neo-angiogenesis and wound healing and this facilitate device functionality.

Implantable biosensor and methods of use thereof

A dialysis adapter cell includes a housing comprising a plurality of pillars extending between and attached to a top plate and a bottom plate to form a hollow receptacle, wherein the top plate comprises an aperture configured to provide access to the hollow receptacle; a dialysis membrane disposed about the housing and sealingly engaged to the top plate and the bottom plate; and a platform in physical communication with the bottom plate and configured to position the dialysis adapter cell in a sample holder of a United States Pharmacopoeia dissolution apparatus 4 flow-through cell.

Dialysis adapter cell and method of release testing of a disperse dosage form

The present invention relates to a variety that contains a recessive gene called the bsg gene and produces peas that exhibit an elevated level of sucrose and a decreased level of alcohol insoluble solids when compared to peas produced from a variety that does not contain the bsg gene within its genome.

Starchless variety of pisum sativum having elevated levels of sucrose

A tissue/implant interface, comprising an implant and a bioactive polymer layer adjacent at least a portion of the outer surface of the implant, wherein the polymer layer contains at least one tissue response modifier covalently attached to the polymer layer or entrapped within the polymer layer in a quantity effective to control the tissue response at the site of implantation. Preferably, the at least one tissue response modifier controls inflammation, fibrosis, and/or neovascularization. Exemplary tissue response modifiers include, but are not limited to, steroidal and non-steroidal anti-inflammatory agents, anti-fibrotic agents, anti-proliferative agents, cytokines, cytokine inhibitors, neutralizing antibodies, adhesive ligands, and combinations thereof. Use of the various combinations of tissue response modifiers with bioactive polymers provides a simple, flexible and effective means to control the implant/tissue interphase, improving implant lifetime and function.

Growing community of inventors

Farmington, CT, United States of America

Diane J Burgess