Bristol-myers Squibb Compnay

Diane E Shevell

Suzanne J Suchard

Marek Honczarenko

Steven G Nadler

John P Throup

Xiaoni Liu

Rong Shi

Dominique Duchesne

Xavier Valencia

Jenny H Xie

Vaishali Shah

Karen D Price

Lixin Lang

Urvi Aras

Christine Kratt

Methods of treating autoimmune diseases, such as systemic lupus erythematosus using domain antibodies that specifically bind human CD28 are provided. The methods may comprise at least one administration cycle comprising one dose of the domain antibody. The method reduces symptoms of systemic lupus erythematosus compared to placebo.

Methods of treating systemic lupus erythematosus using a domain antibody directed against CD28

Methods of treating autoimmune diseases, such as primary immune thrombocytopenia (ITP), solid organ transplant rejection, graft-related disease, pemphigus vulgaris, systemic sclerosis, and myasthenia gravis using antibody polypeptides that specifically bind human CD40L are provided. The antibody polypeptides do not activate platelets. The methods may comprise at least one administration cycle comprising one dose of the antibody polypeptide. The dose may be administered intravenously at a dose from about 75 mg to about 1500 mg. The method normalizes platelet counts in the human patient.

Methods of treating autoimmune disease using a domain antibody directed against CD40L

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Westfield, NJ, United States of America

Diane E Shevell