The United States of America, as Represented by the Secretary, Department of Health and Human Services

Johns Hopkins University

Institute of Organic Chemistry and Biochemistry Ascr, V.v.i.

Diane E Peters

Barbara S Slusher

Stephen H Leppla

Rana Rais

Lukas Tenora

Shi-Hui Liu

Thomas H Bugge

Ivan Snajdr

Jie Liu

Kuang-Hua Chen

Alexander N Wein

Pavel Majer

Disclosed is aprotective antigen (PA) comprising a PA amino acid sequence, wherein one or more of amino acid residues I207, I210, E654, I656, R659, M662, Y681, and L687, as defined by reference to SEQ ID NO: 1, are, independently, substituted, with the proviso that amino acid residue I207 is not substituted with alanine and amino acid residue I210 is not substituted with alanine. Related compositions, nucleic acids, recombinant expression vectors, host cells, populations of cells, methods of treating or preventing cancer in a mammal, and methods of inhibiting the growth of a target cell are also disclosed.

Modified anthrax toxin protective antigen

Growing community of inventors

Grafton, MA, United States of America

Diane E Peters