Centro De Inmunologia Molecular

Diana Rosa Hernández Fernández

Belinda Sánchez Ramírez

Mabel Cruz Rodríguez

Lisset Chao García

Narjara González Suárez

Luis Enrique Fernández Molina

Circe Mesa Pardillo

Jesús Arturo Junco Barranco

Audry Fernández Gómez

Gretchen Bergado Báez

Ángel Alexis Manso Vargas

Blanca Idelmis Tolón Murguía

Miguel Antonio López López

Vicente Guillermo Verez Bencomo

Dayana Pérez Martínez

Gretchen Báez Bergado

This invention describes ways of obtaining nano-particulated adjuvants formed by different synthetic variants of GM3 ganglioside. Depending on the fine structure of the fatty acid in the ceramide of the synthetic GM3, said adjuvants are able to stimulate specifically and in a specialized way the humoral or cellular immune response against accompanying antigens. Particularly, this invention provides immunogenic vaccine compositions that comprise peptides, polypeptides or proteins and the aforementioned nanoparticles, which are formed through the dispersion of hydrophobic proteins of the outer membrane complex (OMC) ofin solutions containing fully synthetic variants of the GM3 ganglioside.

Nano-particles that contain synthetic variants of GM3 ganglioside as adjuvants in vaccines

The present invention relates to the branch of Biotechnology and Medicine, particularly to a method for the selection and treatment of patients with carcinomas of epithelial origin that co-express the HER1 and HER2 receptors without increased expression of these receptors or with the presence of RAS activating mutations. In particular, this method is based on the application of bivalent vaccine compositions which have as active principle the extracellular domains of the HER1 and HER2 receptors or portions thereof and as an adjuvant the very small proteoliposomes derived from the outer membrane proteins ofand the GM3 ganglioside. This method is useful for the treatment of patients whose expression levels of HER1 and HER2 do not allow the monoclonal antibodies against HER1 and/or HER2 to have a therapeutic effect.

Method for the treatment of patients with carcinomas

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Havana, Cuba

Diana Rosa Hernández Fernández