Regeneron Pharmaceuticals, Inc.

Diana M Ahrens

Sean Stevens

Nicholas J Papadopoulos

Joel H Martin

Tammy T Huang

Jeanette L Fairhurst

Ashique Rafique

Kevin J Pobursky

Joan A Windsor

Warren R Mikulka

Ergang Shi

Raymond W Leidich

Marcela Torres

An isolated human antibody or antigen binding fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4R&#x3b1;) with an affinity constant (K) of less than 200 pM, as measured by surface plasmon resonance, is provided.

High affinity human antibodies to human IL-4 receptor

The present invention provides methods for treating one or more diseases or disorders which are improved, inhibited or ameliorated by reducing interleukin-4 (IL-4) activity. The methods of the invention comprise administering to a patient an antibody, or antigen-binding fragment thereof, which specifically binds to a human IL-4 receptor.

An isolated human antibody or antibody fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4R&#x3b1;) with an affinity constant (K) of less than 200 pM, as measured by surface plasmon resonance.

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Mahopac, NY, United States of America

Diana M Ahrens