University of California

Rutgers, the State University of New Jersey

Diana C Roe

Irwin D Kuntz

Jonathan A Ellman

George Lommel Kenyon

Edward Arnold

A Geoffrey Skillman

Christina E Lee

Malin Young

Guangcheng Liu

Allan G Skillman, Jr

Andrew Leavitt

Angelika Muscate

Dolan Eargle

Karl Maurer

Margaret Stauber

Ellen K Kick

Todd J Ewing

The present invention provides non-peptide cathepsin D binding compounds and methods for using such compounds in the detection, labelling and inhibition of cathepsin D.

Nanomolar, non-peptide inhibitors of cathepsin D

The present invention relates to a novel class of compounds that are potent inhibitors of HIV reverse transcriptase and HIV integrase. In addition to being multienzyme inhibitors, the inventive compounds of the present invention are remarkable in at least two other respects. First, they do not appear to be toxic to cells at typical therapeutic concentrations. Second, they appear to be equally effective against mutant strains of HIV reverse transcriptase commonly found in patients who have developed resistance to current reverse transcriptase inhibitors. Because the inventive compounds show promise in combatting viral resistance and are potent inhibitors of both HIV reverse transcriptase and integrase, they are ideal candidates for use in combination with existing therapies or alone in treating AIDS or HIV infection.

Naphthols useful in antiviral methods

Growing community of inventors

Newark, CA, United States of America

Diana C Roe