Merck + Co., Inc.

Diana Benincasa

Steven W Ludmerer

George E Mark, Iii

Gregory Franklin Hollis

Margaret A Cascieri

Michael R Tota

Kathleen A Sullivan

Lin-Lin Shiao

Lyndon J Mitnaul

Methods of identifying inhibitors of the fusion of two types of cells, particularly when fusion is mediated by the interaction of a viral protein and such cellular proteins as CD4 and chemokine receptors, are disclosed. The methods are suitable for identifying substances that are useful for the treatment and prevention of viral diseases. Particularly preferred methods are useful for the identification of inhibitors of HIV-1 infection.

Cell fusion assays using fluorescence resonance energy transfer

The present invention is a series of synthetic virus-like particles useful in the characterization of human papillomavirus infection and assays employing the synthetic virus-like particles.

Synthetic HPV11 virus-like particles

The present invention is a series of synthetic virus-like particles useful in the characterization of human papillomavirus infection and assays employing the synthetic virus-like particles. The synthetic virus-like particles are generated from constructs designated as HPV6:4; HPV6:5; HPV6:2; HPV6:4.DELTA.132; and HPV6:4,S131G.

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Elizabeth, NJ, United States of America

Diana Benincasa