Institute of Pharmacology and Toxicology Academy of Military Medical Sciences Pla China

Academy of Military Medical Sciences

Dian Xiao

Song Li

Wu Zhong

Junhai Xiao

Zhibing Zheng

Xinbo Zhou

Xingzhou Li

Yunde Xie

Xiaokui Wang

Yanming Wang

Ruiyuan Cao

Shiyong Fan

The present application relates to a linker containing arylnitro, an antibody-drug conjugate the linker and use of the linker, as well as a pharmaceutical composition comprising the antibody-drug conjugate and use of the antibody-drug conjugate for treatment and/or prevention of a disease

Linker containing arylnitro, antibody-drug conjugate containing linker and use of linker

Disclosed in the present invention is a compound of Formula (I), a geometric or optical isomer, a pharmaceutically acceptable salt, a solvate or a polymorph thereof. Also disclosed in the present invention is a composition comprising the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof. Also disclosed in the present invention is a use of the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof in the treatment of a disease or disorder such as a hypoglutamatergic condition, a neurodegenerative disease or respiratory depression, particularly in the treatment of a disease or disorder associated with AMPA receptor. 

Brain-targeting prodrug for AMPA receptor synergist, and pharmaceutical applications thereof

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Beijing, China

Dian Xiao