Schering Corporation

Merck Sharp + Dohme Corp.

Dhiru B Vashi

Neil A Lindo

Jeffrey N Clark

John J Piwinski

Pauline C Ting

Daniel M Solomon

Richard J Friary

Frank J Villani

Joe F Lee

Robert G Tyson

James C Towson

Joseph F Lamendola

A process for preparing a compound of formula I ##STR1## wherein R and R' are as described herein. Compounds of formula I are useful as intermediates in the preparation of florfenicol.

Process for preparing intermediates to florfenicol

Disclosed are compounds of Formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein: R.sup.3 is alkyl, alkenyl, alkynyl, aryl, alkaryl, aralkyl, cycloalkyl, acyloxymethyl, alkoxy, alkoxymethyl, or alkyl substituted with cycloalkyl;

Tricyclic derivatives, compositions and methods of use

This invention relates to a novel process for preparing 3-amino-2-methylbenzotrifluoride from benzotrifluoride. The process comprises nitrating benzotrifluoride to form 3-nitrobenzotrifluoride, reacting this compound with trimethyl sulphoxonium halide to form 3-nitro-2-methylbenzotrifluoride and reducing the nitro group to an amino group.

Synthesis of 3-amino-2-methylbenzotrifluoride

This invention relates to organic acid-substituted guanidine compounds. Also disclosed are methods for preparing the compounds, compositions containing them, and methods for their use as anthelmintics.

Organic acid-substituted guanidine anthelmintics

N-((2-nitro)phenyl)-N' (organic acid) guanidine anthelmintics

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Princeton Junction, NJ, United States of America

Dhiru B Vashi