Alembic Limited

Dhiraj Mohansinh Rathod

Pandurang Balwant Deshpande

Parven Kumar Luthra

Hitesh Kantilal Patel

Srinivasan Rengaraju

Pinky Parikh

Milind Moreshwar Gharpure

Nishant Mahendra Patel

Mandar Manohar Deoahar

A process for the preparation of Irbesartan of formula (I) using the steps of:  

Process for preparation of Irbesartan

Processes for the preparation of Venlafaxine (IX) via the novel epoxy-nitrile intermediate (I), which when subjected to hydrogenation forms compound (X), and may subsequently be reduced to yield the desired product (IX). The epoxy-nitrile intermediate (I) itself may be synthesized via various alternative reaction strategies, from a range of starting materials. E.g. 4-methoxy-benzaldehyde (VI), upon treatment with cyclohexyl magnesium bromide yields compound (V). This in turn may be oxidized to yield compound (III), which forms compound (II) on treatment with an (x-keto-halogenation agent. Cyanation of compound (II), then yields the desired epoxy nitrile intermediate (I), from which Venlafaxine (IX) may be synthesized.

Intermediate and processes for its preparation and conversion into a pharmacologically-active agent

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Vadodara, India

Dhiraj Mohansinh Rathod