Council of Scientific and Industrial Research

Dhiman Sarkar

Sampa Sarkar

Swati Pramod Joshi

Roshan Rajan Kulkarni

Ketaki Dilip Shurpali

Sunita Ranjan Deshpande

Preeti Madhukar Chaudhary

Shailaja Pramod Maybhate

Anjali Prabhakar Likhite

Arshad Khan

Sayalee Ramchandra Chavan

Priyanka Sharma

Anjanikumar Jyotiprasad Varma

Ramana Venkata Chepuri

Upasana Singh

Rahul Shivaji Patil

Disclosed herein is an improved process for the preparation of nanostructured oxidized/carboxy cellulose with high carboxy content and high yield, by subjecting non-wood, lignocellulose, sugarcane bagasse derived a-cellulose or cotton cellulose to oxidation at suitable temperature, wherein the particle shape is spherical, particle size of synthesized carboxy cellulose is in the range of 1-100 nm and degree of polymerization (DP) is in the range 50-70 Further the present invention provides pharmaceutical composition comprising of nanostructured oxidized/carboxy celluloses preferably 6-carboxy cellulose, and 2,3,6-tricarboxycellulose alone or in association with one or more pharmaceutically acceptable carrier(s) or excipient(s) for treatment of microbial infections. The carboxycelluloses were efficient in stabilizing multi-walled carbon nanotubes and single-walled carbon nanotubes in aqueous media.

Synthesis of nanostructured carboxycelluloses from non-wood cellulose

The present invention describes the use of pharmaceutical compositions including compounds of formula 2 (below) for treatment of infections related toand for anti-proliferative activity. Also, the present invention discloses a process of extraction of compounds of formula 2 from the extract of aerial parts of: 

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The present invention discloses functional nitrite reductase as a potential drug target for anti-tubercular drug development. The present invention also relates to the development of an easy method for identification of nitrite in clinical samples as well as its correlation with the severity of the disease. Presence of active as well as dormant/latent stages of(MTB) could be identified from nitrite in clinical samples like sputum of potential TB patients.

Nitrite-reductase (NIRB) as potential anti-tubercular target and a method to detect the severity of tuberculosis disease

Disclosed herein is 10-&#x3b1;/&#x3b2;-D-Arabinofuranosylundecenes of general Formula (II) or pharmaceutically acceptable salts thereof as anti-mycobacterial agents in vitro; (II) wherein R, R1 and R&#x2033; are as defined herein in the specification. The present invention also discloses a simple stereoselective synthesis 10-&#x3b1;/&#x3b2;-D-Arabinofuranosylundecenes of Formula (II) to target enzymes involved in the biosynthesis of cell wall ofand thus useful as inhibitors in thedrug development. 

10-&#x3b1;/&#x3b2;-D-arabinofuranosyl-undecenes as potential anti-mycobacterial agents and process for the preparation thereof

This invention relates to diterpenes of general formula (1) belonging to labdane class, isolated from, being useful for prevention, treatment, inhibition or controlling growth and proliferation of mycobacterial activity in mammals. The invention further discloses process for isolation of the fractions containing the same. 

C-9 oxygen functionalized labdane derivates

Triazole derivatives useful as anti-tubercular compounds; process for preparation of the triazoles and a method for inhibiting growth ofBCG andH37Ra using the triazoles.

1, 2, 4-triazole derivatives and their anti-microbial activity

Active fractions exhibiting anti-tuberculous activity from the plant(family&#x2014;Sterculiaceae) are described. Methanol extracts of the aerial part ofexhibited activity against MtbGS in primary screening of biosynthetic assay. Subsequent fractionation was carried out in organic solvents. Out of all these, two fractions (fraction D and K) are exhibiting inhibitory activity againstglutamine synthetase activity. These fractions D and K are inhibiting 74% and 44% respectively at 7.5 mg/ml concentrations. The determined ICvalue of the fraction K is found to be 4.5 mg/ml from the dose response curve against the purifiedGlutamine Synthetase. The ICvalue forBCG is 1.56 &#x3bc;g/ml. It was observed that there was no significant effect on proliferation of HL-60 cell line at 10&#xd7;MIC levels of the hits. This data indicated that these compounds could be initially considered to be safe.

Invention provides antitubercular compounds selected from propargylated 1,2,3 triazoles of Formula I, wherein, X is sulfur(S) or a sulphone (A), n, m represent independently an integer O or 1, with the provision that when 'n' is 1, 'm' is 1; R1 is hydrogen; C1-C6 linear or branched alkyl group optionally substituted with aryl group; halogen; or aryl group optionally substituted with &#x2014;OCH3, halogen, and nitro; R2 and R3 are selected from the group consisting of hydrogen, C1-C6 alkyl optionally substituted with heterocyclic ring of 5 to 6 ring atoms containing one to three hetero atoms selected from oxygen, sulfur, nitrogen, which may be substituted with alkyl, arylalkyl, linear or branched alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or allyl or propargyl groups consisting of 1 to 6 carbon atoms; Z is C1-C6 alkyl optionally substituted with heterocyclic ring of 1 to 6 ring atoms, containing one to three hetero atoms selected from oxygen, sulfur, nitrogen, which may be substituted with arylalkyl, linear or branched alkenyl, substituted alkenyl, alkynyl, substituted alkynyl allyl or propargyl groups consisting of 1 to 6 carbon atoms; with the provision that when &#x2018;m&#x2019; is 1, and &#x2018;n&#x2019; is zero; R1 is selected from the group consisting of hydrogen, halogen; C1-C6 linear or branched alkyl group optionally substituted with aryl group or aryl group optionally substituted with &#x2014;OCH3, halogen, and nitro, R2 and R3 are selected from the group consisting of hydrogen, C1-C6 alkyl optionally substituted with heterocyclic ring of 5 to 6 ring atoms containing one to three hetero atoms selected from oxygen, sulfur, nitrogen, which may be substituted with alkyl, arylalkyl, linear or branched alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or allyl or propargyl groups consisting of 1 to 6 carbon atoms; Z is selected from the group consisting of halogen, C1-C6 linear or branched alkyl group optionally substituted with heterocyclic ring of 1 to 6 ring atoms, containing one to three hetero atoms selected from oxygen, sulfur, nitrogen, wherein the heterocyclic ring may further be substituted with halogen, alkyl, arylalkyl.

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Pune, India

Dhiman Sarkar